methyl (R)-2-[(1s,4S)-4-hydroxycyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Base Information

Chemical Name:methyl (R)-2-[(1s,4S)-4-hydroxycyclohexyl]-2-(2-nitrophenylsulfonamido)acetate
CAS No.:1372805-32-7
Molecular Formula:C₁₅H₂₀N₂O₇S
Molecular Weight:372.399
Hs Code.:

Synonyms:methyl (R)-2-[(1s,4S)-4-hydroxycyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

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Chemical Property of methyl (R)-2-[(1s,4S)-4-hydroxycyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Chemical Property:

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Technology Process of methyl (R)-2-[(1s,4S)-4-hydroxycyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

There total 3 articles about methyl (R)-2-[(1s,4S)-4-hydroxycyclohexyl]-2-(2-nitrophenylsulfonamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 143323-49-3,141518-55-0
(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate

: C₁₅H₂₀N₂O₇S

: 1372805-32-7
methyl (R)-2-[(1s,4S)-4-hydroxycyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Guidance literature:: (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate; With Rh/Al₂O₃; hydrogen; acetic acid; at 35 ℃; for 18h; under 3750.38 Torr;

With hydrogenchloride; In 1,4-dioxane; water; at 25 ℃; for 2h;

2-Nitrobenzenesulfonyl chloride; Further stages;
DOI:10.1055/s-0031-1289724

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: C₁₅H₂₀N₂O₇S

: 1372805-32-7
methyl (R)-2-[(1s,4S)-4-hydroxycyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetyl chloride / 19.5 h / 0 - 55 °C / Inert atmosphere; Large scale reaction

2.1: triethylamine / dichloromethane / 0.08 h / 25 °C / Large scale reaction

2.2: 20.75 h / 25 °C / Large scale reaction

3.1: Rh/Al₂O₃; hydrogen; acetic acid / 18 h / 35 °C / 3750.38 Torr

3.2: 2 h / 25 °C

With Rh/Al₂O₃; hydrogen; acetic acid; triethylamine; acetyl chloride; In dichloromethane;
DOI:10.1055/s-0031-1289724

Reference yield:

: 57591-61-4,68697-60-9,127369-30-6,134694-94-3
methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride

: C₁₅H₂₀N₂O₇S

: 1372805-32-7
methyl (R)-2-[(1s,4S)-4-hydroxycyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.08 h / 25 °C / Large scale reaction

1.2: 20.75 h / 25 °C / Large scale reaction

2.1: Rh/Al₂O₃; hydrogen; acetic acid / 18 h / 35 °C / 3750.38 Torr

2.2: 2 h / 25 °C

With Rh/Al₂O₃; hydrogen; acetic acid; triethylamine; In dichloromethane;
DOI:10.1055/s-0031-1289724