methyl (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Base Information

Chemical Name:methyl (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate
CAS No.:1372805-34-9
Molecular Formula:C₂₀H₂₉N₃O₈S
Molecular Weight:471.532
Hs Code.:

Synonyms:methyl (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

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Chemical Property of methyl (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

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Technology Process of methyl (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

There total 7 articles about methyl (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₁₅H₂₁N₃O₆S

: 1372805-34-9
methyl (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃; for 18h; Large scale reaction;
DOI:10.1055/s-0031-1289724

Reference yield:

: 1372805-32-7
methyl (R)-2-[(1s,4S)-4-hydroxycyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

: 1372805-34-9
methyl (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1.5 h / 5 - 20 °C / Inert atmosphere; Large scale reaction

2.1: sodium azide / N,N-dimethyl-formamide / 16 h / 55 °C / Large scale reaction

3.1: triphenylphosphine / ethyl acetate / 1.5 h / 65 °C / Large scale reaction

3.2: 1.5 h / 65 °C / Large scale reaction

4.1: triethylamine / dichloromethane / 18 h / 25 °C / Large scale reaction

With sodium azide; triethylamine; triphenylphosphine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1055/s-0031-1289724

Reference yield:

: 1372805-33-8
methyl (R)-2-[(1s,4S)-4-(methylsulfonyloxy)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

: 1372805-34-9
methyl (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / N,N-dimethyl-formamide / 16 h / 55 °C / Large scale reaction

2.1: triphenylphosphine / ethyl acetate / 1.5 h / 65 °C / Large scale reaction

2.2: 1.5 h / 65 °C / Large scale reaction

3.1: triethylamine / dichloromethane / 18 h / 25 °C / Large scale reaction

With sodium azide; triethylamine; triphenylphosphine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1055/s-0031-1289724