(R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetic acid

Base Information

Chemical Name:(R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetic acid
CAS No.:1372805-35-0
Molecular Formula:C₁₉H₂₇N₃O₈S
Molecular Weight:457.505
Hs Code.:

Synonyms:(R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetic acid

Suppliers and Price of (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetic acid

There total 7 articles about (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1372805-34-9
methyl (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

: 1372805-35-0
(R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetic acid

Guidance literature:: methyl (R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate; With sodium hydroxide; In methanol; water; at 50 ℃; for 1h;

With citric acid; In water; pH=4;
DOI:10.1055/s-0031-1289724

Reference yield:

: 1372805-32-7
methyl (R)-2-[(1s,4S)-4-hydroxycyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

: 1372805-35-0
(R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 1.5 h / 5 - 20 °C / Inert atmosphere; Large scale reaction

2.1: sodium azide / N,N-dimethyl-formamide / 16 h / 55 °C / Large scale reaction

3.1: triphenylphosphine / ethyl acetate / 1.5 h / 65 °C / Large scale reaction

3.2: 1.5 h / 65 °C / Large scale reaction

4.1: triethylamine / dichloromethane / 18 h / 25 °C / Large scale reaction

5.1: sodium hydroxide / methanol; water / 1 h / 50 °C

5.2: pH 4

With sodium azide; triethylamine; triphenylphosphine; sodium hydroxide; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1055/s-0031-1289724

Reference yield:

: 1372805-33-8
methyl (R)-2-[(1s,4S)-4-(methylsulfonyloxy)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate

: 1372805-35-0
(R)-2-[(1r,4R)-4-(tert-butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / N,N-dimethyl-formamide / 16 h / 55 °C / Large scale reaction

2.1: triphenylphosphine / ethyl acetate / 1.5 h / 65 °C / Large scale reaction

2.2: 1.5 h / 65 °C / Large scale reaction

3.1: triethylamine / dichloromethane / 18 h / 25 °C / Large scale reaction

4.1: sodium hydroxide / methanol; water / 1 h / 50 °C

4.2: pH 4

With sodium azide; triethylamine; triphenylphosphine; sodium hydroxide; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1055/s-0031-1289724