S-1-(2-chlorophenyl)-2-cyanoethyl thioacetate

Base Information

Chemical Name:S-1-(2-chlorophenyl)-2-cyanoethyl thioacetate
CAS No.:1392592-80-1
Molecular Formula:C₁₁H₁₀ClNOS
Molecular Weight:239.725
Hs Code.:

Synonyms:S-1-(2-chlorophenyl)-2-cyanoethyl thioacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of S-1-(2-chlorophenyl)-2-cyanoethyl thioacetate

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Technology Process of S-1-(2-chlorophenyl)-2-cyanoethyl thioacetate

There total 2 articles about S-1-(2-chlorophenyl)-2-cyanoethyl thioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.3%

: 51220-00-9
(E)-3-(2-chlorophenyl)-2-propenenitrile

: 507-09-5
tiolacetic acid

: 1392592-80-1
S-1-(2-chlorophenyl)-2-cyanoethyl thioacetate

Guidance literature:: With tributyl-amine; In toluene; at 75 - 85 ℃; for 5h; Inert atmosphere;
DOI:10.1055/s-0031-1289773

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 1392592-80-1
S-1-(2-chlorophenyl)-2-cyanoethyl thioacetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / Inert atmosphere; Reflux

2: tributyl-amine / toluene / 5 h / 75 - 85 °C / Inert atmosphere

With tributyl-amine; potassium hydroxide; In toluene; 2: Michael addition;
DOI:10.1055/s-0031-1289773

Reference yield:

: 1392592-80-1
S-1-(2-chlorophenyl)-2-cyanoethyl thioacetate

: 1392592-76-5
3-amino-1-(2-chlorophenyl)propane-1-sulfonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 12 h / Cooling with ice

2: formic acid; dihydrogen peroxide / water / 12 h

With lithium aluminium tetrahydride; formic acid; dihydrogen peroxide; In diethyl ether; water;
DOI:10.1055/s-0031-1289773