2-(benzyloxy)-3,5-dibromopyridine

Base Information

• Chemical Name: 2-(benzyloxy)-3,5-dibromopyridine
• CAS No.: 130284-00-3
• Molecular Formula: C₁₂H₉Br₂NO
• Molecular Weight: 343.018
• Mol file: 130284-00-3.mol

Synonyms:2-(benzyloxy)-3,5-dibromopyridine

Chemical Property of 2-(benzyloxy)-3,5-dibromopyridine

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(Benzyloxy)-3,5-dibromopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(benzyloxy)-3,5-dibromopyridine

There total 2 articles about 2-(benzyloxy)-3,5-dibromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,5-dibromo-2-hydroxypyridine (13472-81-6) + benzyl bromide (100-39-0) → 2-(benzyloxy)-3,5-dibromopyridine (130284-00-3)

Guidance literature:

With silver carbonate; In benzene; at 40 - 50 ℃; for 24h;

DOI:10.3987/COM-89-5142

Reference yield: 55.0%

2,3,5-tribromopyridine (75806-85-8) + benzyl alcohol (100-51-6,185532-71-2) → 2-(benzyloxy)-3,5-dibromopyridine (130284-00-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 3h;

Reference yield: 21.0%

oxetan-3-one (6704-31-0) + 2-(benzyloxy)-3,5-dibromopyridine (130284-00-3) → 3-(2-(benzyloxy)-5-bromopyridin-3-yl)oxetan-3-ol

Guidance literature:

2-(benzyloxy)-3,5-dibromopyridine; With n-butyllithium; In diethyl ether; at -78 - -70 ℃; for 0.5h;

oxetan-3-one; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 4h;

upstream raw materials:

3,5-dibromo-2-hydroxypyridine

benzyl bromide

2,3,5-tribromopyridine

benzyl alcohol

Refernces

• 1、 Shiao, Min-Jen,Tarng, Kai-Yih. "A FACILE SYNTHESIS OF BROMO-2-ALKOXYPYRIDINES". . p. 819 - 824. Retrieved 2007/10/02.