4-(5-amino-4-(4-fluorophenyl)-3-(pyridine-4-yl)-1H-pyrazol-1-yl)benzonitrile

Base Information

Chemical Name:4-(5-amino-4-(4-fluorophenyl)-3-(pyridine-4-yl)-1H-pyrazol-1-yl)benzonitrile
CAS No.:1353634-58-8
Molecular Formula:C₂₁H₁₄FN₅
Molecular Weight:355.374
Hs Code.:

Synonyms:4-(5-amino-4-(4-fluorophenyl)-3-(pyridine-4-yl)-1H-pyrazol-1-yl)benzonitrile

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Chemical Property of 4-(5-amino-4-(4-fluorophenyl)-3-(pyridine-4-yl)-1H-pyrazol-1-yl)benzonitrile

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Technology Process of 4-(5-amino-4-(4-fluorophenyl)-3-(pyridine-4-yl)-1H-pyrazol-1-yl)benzonitrile

There total 4 articles about 4-(5-amino-4-(4-fluorophenyl)-3-(pyridine-4-yl)-1H-pyrazol-1-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 459-22-3
4-fluorophenylacetonitrile

: 1353634-75-9
N-(4-cyanophenyl)pyridine-4-carbohydrazonoyl chloride

: 1353634-58-8
4-(5-amino-4-(4-fluorophenyl)-3-(pyridine-4-yl)-1H-pyrazol-1-yl)benzonitrile

Guidance literature:: 4-fluorophenylacetonitrile; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.75h;

N-(4-cyanophenyl)pyridine-4-carbohydrazonoyl chloride; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1021/jm201391u

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 1353634-58-8
4-(5-amino-4-(4-fluorophenyl)-3-(pyridine-4-yl)-1H-pyrazol-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / Reflux

2.1: N-chloro-succinimide / N,N-dimethyl-formamide

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C

3.2: 1 h / -78 °C

With N-chloro-succinimide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm201391u

Reference yield:

: 17672-27-4
4-hydrazinobenzonitrile

: 1353634-58-8
4-(5-amino-4-(4-fluorophenyl)-3-(pyridine-4-yl)-1H-pyrazol-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / Reflux

2.1: N-chloro-succinimide / N,N-dimethyl-formamide

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C

3.2: 1 h / -78 °C

With N-chloro-succinimide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm201391u