1-benzyloxy-2-(tert-butyldimethylsilyloxymethyl)-8-(p-methoxybenzyloxy)-3-octyn-2-ol

Base Information

Chemical Name:1-benzyloxy-2-(tert-butyldimethylsilyloxymethyl)-8-(p-methoxybenzyloxy)-3-octyn-2-ol
CAS No.:1314558-91-2
Molecular Formula:C₃₀H₄₄O₅Si
Molecular Weight:512.762
Hs Code.:

Synonyms:1-benzyloxy-2-(tert-butyldimethylsilyloxymethyl)-8-(p-methoxybenzyloxy)-3-octyn-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzyloxy-2-(tert-butyldimethylsilyloxymethyl)-8-(p-methoxybenzyloxy)-3-octyn-2-ol

Chemical Property:

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Technology Process of 1-benzyloxy-2-(tert-butyldimethylsilyloxymethyl)-8-(p-methoxybenzyloxy)-3-octyn-2-ol

There total 1 articles about 1-benzyloxy-2-(tert-butyldimethylsilyloxymethyl)-8-(p-methoxybenzyloxy)-3-octyn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154458-57-8
1-benzyloxy-3-(tert-butyldimethylsilyloxy)propan-2-one

: 123186-35-6
1-[(hex-5-yn-1-yloxy)methyl]-4-methoxybenzene

: 1314558-91-2
1-benzyloxy-2-(tert-butyldimethylsilyloxymethyl)-8-(p-methoxybenzyloxy)-3-octyn-2-ol

Guidance literature:: 1-benzyloxy-3-(tert-butyldimethylsilyloxy)propan-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -40 ℃; for 1h; Inert atmosphere;

1-[(hex-5-yn-1-yloxy)methyl]-4-methoxybenzene; In tetrahydrofuran; hexane; at -40 - 20 ℃; Inert atmosphere;

With water; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2011.05.064

Reference yield:

: 1314558-91-2
1-benzyloxy-2-(tert-butyldimethylsilyloxymethyl)-8-(p-methoxybenzyloxy)-3-octyn-2-ol

: 124-63-0
methanesulfonyl chloride

: C₃₁H₄₆O₇SSi

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.064

Reference yield:

: 1314558-91-2
1-benzyloxy-2-(tert-butyldimethylsilyloxymethyl)-8-(p-methoxybenzyloxy)-3-octyn-2-ol

: 1314559-54-0
N-(tert-butoxycarbonyl)-2-[1-benzyloxy-2-(tert-butyldimethylsilyloxymethyl)-8-(p-methoxybenzyloxy)-2,3-octadien-4-yl]aniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.1: copper(I) bromide dimethylsulfide complex; n-butyllithium; tri-n-butyl-tin hydride; diisopropylamine / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

2.2: 6 h / 70 °C / Inert atmosphere

With n-butyllithium; copper(I) bromide dimethylsulfide complex; tri-n-butyl-tin hydride; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; 2.2: Stille coupling;
DOI:10.1016/j.tet.2011.05.064