123186-35-6Relevant articles and documents
Dictating Thermodynamic Control through Tethering: Applications to Stereoselective Bis-Spiroketal Synthesis
Asari, Austin H.,Floreancig, Paul E.
, p. 6622 - 6626 (2020)
Approaches to stereocontrol that invoke thermodynamic control fail when two or more potential products are energetically similar, but rational structural perturbations can be employed to break the energetic degeneracy and provide selective transformations. This manuscript illustrates that tethering is an effective approach for the stereoselective construction of bis-spiroketals with thermodynamically similar stereoisomers, providing a new approach to set remote stereocenters and prepare complex structures that have not previously been accessed stereoselectively.
SYNTHESIS OF DELTA 12-PGJ3 AND RELATED COMPOUNDS
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Page/Page column 133, (2015/04/15)
In one aspect, the present invention provides novel derivatives of Δ12-PGJ3 and modular synthetic pathways to obtaining Δ12-PGJ3 and derivatives thereof. In some aspects, the present derivatives of Δ12-PGJ3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.
Sustainable, mild and efficient p-methoxybenzyl ether deprotections utilizing catalytic DDQ
Walsh, Katie,Sneddon, Helen F.,Moody, Christopher J.
, p. 7380 - 7387 (2017/09/13)
A procedure for the selective deprotection of p-methoxybenzyl ethers using catalytic amounts of DDQ and of sodium nitrite, with oxygen as the terminal oxidant, is reported.
