2-bromo-6-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)benzyl acetate

Base Information

Chemical Name:2-bromo-6-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)benzyl acetate
CAS No.:1346674-24-5
Molecular Formula:C₂₁H₂₃BrN₂O₃
Molecular Weight:431.329
Hs Code.:

Synonyms:2-bromo-6-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)benzyl acetate

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Chemical Property of 2-bromo-6-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)benzyl acetate

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Technology Process of 2-bromo-6-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)benzyl acetate

There total 16 articles about 2-bromo-6-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)benzyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1147858-83-0
acetic acid 2,6-dibromobenzyl ester

: 1346674-23-4
7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo-[1,2-a]pyrazin-1(6H)-one

: 1346674-24-5
2-bromo-6-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)benzyl acetate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 120 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b01147

Reference yield:

: 1346674-23-4
7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo-[1,2-a]pyrazin-1(6H)-one

: 2-bromo-6-iodobenzyl acetate

: 1346674-24-5
2-bromo-6-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)benzyl acetate

: C₂₁H₂₃IN₂O₃

Guidance literature:: With copper(l) iodide; caesium carbonate; In 1,4-dioxane; at 105 ℃; for 16h;

Reference yield:

: 69321-60-4
2,6-dibromotoluene

: 1346674-24-5
2-bromo-6-(7,7-dimethyl-1-oxo-3,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2(6H)-yl)benzyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 14 h / 80 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 14 h / 20 °C / Inert atmosphere

3: caesium carbonate / N,N,N,N,-tetramethylethylenediamine; copper(l) iodide / 1,2-dimethoxyethane / 3 h / 150 °C / microwave irradiation

With N-Bromosuccinimide; caesium carbonate; copper(l) iodide; 2,2'-azobis(isobutyronitrile); N,N,N,N,-tetramethylethylenediamine; In tetrachloromethane; 1,2-dimethoxyethane; N,N-dimethyl-formamide;