15-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-13-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2,4,10,14-tetramethyl-pentadeca-6,8,10,14-tetraenal

Base Information

• Chemical Name: 15-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-13-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2,4,10,14-tetramethyl-pentadeca-6,8,10,14-tetraenal
• CAS No.: 496918-08-2
• Molecular Formula: C₇₁H₁₀₀O₇Si₃
• Molecular Weight: 1149.83

Synonyms:15-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-13-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2,4,10,14-tetramethyl-pentadeca-6,8,10,14-tetraenal

Chemical Property of 15-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-13-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2,4,10,14-tetramethyl-pentadeca-6,8,10,14-tetraenal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 15-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-13-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2,4,10,14-tetramethyl-pentadeca-6,8,10,14-tetraenal

There total 15 articles about 15-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-13-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2,4,10,14-tetramethyl-pentadeca-6,8,10,14-tetraenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-tert-butyl-6-[3-(tert-butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-15-hydroxy-2,6,12,14-tetramethyl-pentadeca-1,5,7,9-tetraenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one (299179-96-7) → 15-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-13-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2,4,10,14-tetramethyl-pentadeca-6,8,10,14-tetraenal (496918-08-2)

Guidance literature:

With pyridine; Dess-Martin periodane; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.3987/com-02-s(m)17

Reference yield:

(E)-3-[(2R,5S,6S,9R)-2-tert-Butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-2-methyl-acrylic acid ethyl ester (146983-25-7) → 15-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-13-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2,4,10,14-tetramethyl-pentadeca-6,8,10,14-tetraenal (496918-08-2)

Guidance literature:

Multi-step reaction with 10 steps

1: 82 percent / DIBAL-H / CH₂Cl₂ / -78 °C

2: 92 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 °C

3: toluene / 5 h / -78 °C

4: 99 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

5: 71 percent / (DHQD)2-PHAL; Ad-mix β; OsO4 / 2-methyl-propan-2-ol; H2O; toluene / 24 h

6: 94 percent / periodic acid / tetrahydrofuran / 2 h / 20 °C

7: 83 percent / toluene / 20 h / 85 °C

8: 82 percent / CrCl₂ / tetrahydrofuran / 1.5 h / 20 °C

9: 83 percent / Pd(PPh₃)4; TlOEt / tetrahydrofuran; H₂O / 0.25 h

10: 86 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; 2,6-dimethylpyridine; chromium dichloride; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; thallium (I) ethoxide; diisobutylaluminium hydride; Dess-Martin periodane; dimethyl sulfoxide; periodic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; In tetrahydrofuran; dichloromethane; water; toluene; tert-butyl alcohol; 2: Swern oxidation / 5: Sharpless dihydroxylation / 8: Takai reaction / 9: Suzuki cross coupling / 10: Dess-Martin oxidation;

DOI:10.3987/com-02-s(m)17

Reference yield:

(2R,2R,4S,5R)-spiro-1-[(tert-butyldiphenylsilyloxy)methyl]-2-methyl-5-(2-methylpropen-1-ol)cyclohex-1-ene-(4,5')-2'-tert-butyl-1',3'-dioxolan-4'-ol (497065-29-9) → 15-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-13-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2,4,10,14-tetramethyl-pentadeca-6,8,10,14-tetraenal (496918-08-2)

Guidance literature:

Multi-step reaction with 9 steps

1: 92 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 °C

2: toluene / 5 h / -78 °C

3: 99 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

4: 71 percent / (DHQD)2-PHAL; Ad-mix β; OsO4 / 2-methyl-propan-2-ol; H2O; toluene / 24 h

5: 94 percent / periodic acid / tetrahydrofuran / 2 h / 20 °C

6: 83 percent / toluene / 20 h / 85 °C

7: 82 percent / CrCl₂ / tetrahydrofuran / 1.5 h / 20 °C

8: 83 percent / Pd(PPh₃)4; TlOEt / tetrahydrofuran; H₂O / 0.25 h

9: 86 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; 2,6-dimethylpyridine; chromium dichloride; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; thallium (I) ethoxide; Dess-Martin periodane; dimethyl sulfoxide; periodic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; In tetrahydrofuran; dichloromethane; water; toluene; tert-butyl alcohol; 1: Swern oxidation / 4: Sharpless dihydroxylation / 7: Takai reaction / 8: Suzuki cross coupling / 9: Dess-Martin oxidation;

DOI:10.3987/com-02-s(m)17

upstream raw materials:

2-tert-butyl-6-[3-(tert-butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-15-hydroxy-2,6,12,14-tetramethyl-pentadeca-1,5,7,9-tetraenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one

(2S,4S,5S)-5-<(tert-Butyldiphenylsilyl)oxy>-7-dibromo-2,4-dimethyl-6-heptenol

(2'S,4S,4'S,5'S)-3-<5'-<(tert-Butyldiphenylsilyl)oxy>-7'-dibromo-2',4'-dimethylhept-6'-enoyl>-4-isopropyl-1,3-oxazolidin-2-one

(2R,2R,4S,5R)-spiro-1-[(tert-butyldiphenylsilyloxy)methyl]-2-methyl-5-(2-methylpropen-1-ol)cyclohex-1-ene-(4,5')-2'-tert-butyl-1',3'-dioxolan-4'-ol

Downstream raw materials:

C₇₇H₁₀₈O₈Si₃

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 496918-08-2 15-[2-tert-butyl-8-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-4-oxo-1,3-dioxa-spiro[4.5]dec-7-en-6-yl]-13-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxy)-2,4,10,14-tetramethyl-pentadeca-6,8,10,14-tetraenal

Send

Send

Metric Ton KG G Pound L ML

Send

Send