(1S,1'R)-6,7-dimethoxy-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(1S,1'R)-6,7-dimethoxy-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:123190-13-6
Molecular Formula:C₂₀H₂₅NO₃
Molecular Weight:327.423
Hs Code.:

Synonyms:(1S,1'R)-6,7-dimethoxy-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of (1S,1'R)-6,7-dimethoxy-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,1'R)-6,7-dimethoxy-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (1S,1'R)-6,7-dimethoxy-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline

There total 16 articles about (1S,1'R)-6,7-dimethoxy-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 917-64-6
methyl magnesium iodide

: 123284-47-9
(3S,10bR)-8,9-dimethoxy-3-phenyl-2,3,5,6-tetrahydro-10bH-oxazolo<2.3-a>isoquinoline

: 123190-13-6,132283-73-9
(1S,1'S)-6,7-dimethoxy-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: In diethyl ether; at -78 ℃; for 1h;
DOI:10.1016/S0040-4020(01)87916-3

Reference yield: 93.0%

: 917-64-6
methyl magnesium iodide

: 123285-94-9
(3R,10bS)-8,9-dimethoxy-3-phenyl-2,3,5,6-tetrahydro-10bH-oxazolo<2.3-a>isoquinoline

: 123190-13-6
(1S,1'R)-6,7-dimethoxy-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: In diethyl ether; at -78 ℃; for 1h;
DOI:10.1016/S0040-4020(01)87916-3

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 123190-13-6
(1S,1'R)-6,7-dimethoxy-2-(2-hydroxy-1-phenylethyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol; acetic acid / 5 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 1 h / -78 °C

3: 93 percent / diethyl ether / 1 h / -78 °C

With triethylamine; In diethyl ether; ethanol; dichloromethane; acetic acid;
DOI:10.1016/S0040-4020(01)87916-3