1-(2-(pyridin-2-yl)phenyl)methanol

Base Information

• Chemical Name: 1-(2-(pyridin-2-yl)phenyl)methanol
• CAS No.: 98061-37-1
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.225
• Mol file: 98061-37-1.mol

Synonyms:1-(2-(pyridin-2-yl)phenyl)methanol

Chemical Property of 1-(2-(pyridin-2-yl)phenyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-(2-(pyridin-2-yl)phenyl)methanol

There total 12 articles about 1-(2-(pyridin-2-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-phenylpyridine (1008-89-5) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 1-(2-(pyridin-2-yl)phenyl)methanol (98061-37-1)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; sodium acetate; zinc dibromide; In 1,2-dichloro-ethane; at 60 ℃; for 24h; Solvent; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.7b00183

Reference yield: 94.0%

ethyl 2-(pyridin-2-yl)benzoate (28901-52-2) → 1-(2-(pyridin-2-yl)phenyl)methanol (98061-37-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 1h; Ambient temperature;

DOI:10.1246/bcsj.58.3547

Reference yield: 91.0%

2-bromo-pyridine (109-04-6) + 3H-benzo[c][1,2]oxaborol-1-ol (5735-41-1) → 1-(2-(pyridin-2-yl)phenyl)methanol (98061-37-1)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 90 ℃; for 4h;

DOI:10.1016/j.tet.2007.06.099

upstream raw materials:

2-iodopyridine

benzyl alcohol

ethyl 2-(pyridin-2-yl)benzoate

methyl 2-(2-pyridinyl)benzoate

Downstream raw materials:

formaldehyd

5H-indeno[1,2-b]pyridin-5-one

6H-pyrido[2,1-a]isoindolylium bromide

2-(2-methylphenyl)pyridine