(2R)-2-[6-(4-Chlorophenoxy)hexyl]-2,3-dihydroxypropionic acid ethyl ester

Base Information

Chemical Name:(2R)-2-[6-(4-Chlorophenoxy)hexyl]-2,3-dihydroxypropionic acid ethyl ester
CAS No.:314263-48-4
Molecular Formula:C₁₇H₂₅ClO₅
Molecular Weight:344.835
Hs Code.:
DSSTox Substance ID:DTXSID301161478
Nikkaji Number:J1.484.115F

Synonyms:DTXSID301161478;(2R)-2-[6-(4-Chlorophenoxy)hexyl]-2,3-dihydroxypropionic acid ethyl ester;Ethyl (2R)-8-(4-chlorophenoxy)-2-hydroxy-2-(hydroxymethyl)octanoate;314263-48-4

Suppliers and Price of (2R)-2-[6-(4-Chlorophenoxy)hexyl]-2,3-dihydroxypropionic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-[6-(4-Chlorophenoxy)hexyl]-2,3-dihydroxypropionic acid ethyl ester

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:12
Exact Mass:344.1390516
Heavy Atom Count:23
Complexity:331

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(CCCCCCOC1=CC=C(C=C1)Cl)(CO)O
Isomeric SMILES:CCOC(=O)[C@@](CCCCCCOC1=CC=C(C=C1)Cl)(CO)O

Technology Process of (2R)-2-[6-(4-Chlorophenoxy)hexyl]-2,3-dihydroxypropionic acid ethyl ester

There total 2 articles about (2R)-2-[6-(4-Chlorophenoxy)hexyl]-2,3-dihydroxypropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37136-99-5
1-((6-bromohexyl)oxy)-4-chlorobenzene

: 314263-48-4
ethyl (R)-2,3-dihydroxy-2-[6-(p-chlorophenoxy)hexyl]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent

2: 96 percent / NMO; water; OsO₄ / toluene; 2-methyl-propan-2-ol / 1 h / 20 °C

3: 44 percent / Amano AK / various solvent(s) / 2 h / 20 °C / Enzymatic reaction

With osmium(VIII) oxide; N-methyl-2-indolinone; Amano AK; water; In toluene; tert-butyl alcohol; 2: dihydroxylation / 3: kinetic resolution;
DOI:10.1016/S0957-4166(00)00304-9

Reference yield:

: 82258-37-5
ethyl 2-[6-(p-chlorophenoxy)hexyl]acrylate

: 314263-48-4
ethyl (R)-2,3-dihydroxy-2-[6-(p-chlorophenoxy)hexyl]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / NMO; water; OsO₄ / toluene; 2-methyl-propan-2-ol / 1 h / 20 °C

2: 44 percent / Amano AK / various solvent(s) / 2 h / 20 °C / Enzymatic reaction

With osmium(VIII) oxide; N-methyl-2-indolinone; Amano AK; water; In toluene; tert-butyl alcohol; 1: dihydroxylation / 2: kinetic resolution;
DOI:10.1016/S0957-4166(00)00304-9

Reference yield:

: 314263-48-4
ethyl (R)-2,3-dihydroxy-2-[6-(p-chlorophenoxy)hexyl]propanoate

: 124083-20-1,828934-40-3
(R)-(+)-etomoxir

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2: potassium carbonate / ethanol / 6 h / 20 °C

With potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; 1: mesylation / 2: Cyclization;
DOI:10.1016/S0957-4166(00)00304-9