(E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

Base Information

• Chemical Name: (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate
• CAS No.: 1346502-21-3
• Molecular Formula: C₂₇H₃₉N₃O₆
• Molecular Weight: 501.623
• Mol file: 1346502-21-3.mol

Synonyms:(E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

Chemical Property of (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

There total 10 articles about (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate (1346502-20-2) → (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate (1346502-21-3)

Guidance literature:

(E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate; With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;

With water; In tetrahydrofuran; at 60 ℃;

DOI:10.1021/jm2009106

Reference yield:

(E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate (1346502-40-6) → (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate (1346502-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C

2.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

2.2: 60 °C

With sodium azide; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm2009106

Reference yield:

2-choro-5-iodopyridine (69045-79-0) → (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate (1346502-21-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 150 °C / Microwave irradiation

2.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 0.83 h / 0 - 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C

5.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

5.2: 60 °C

With dmap; sodium azide; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm2009106

upstream raw materials:

2-choro-5-iodopyridine

4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene

(E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

2-(2-(2-(2-(5-iodopyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethanol

Downstream raw materials:

2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)-N,N-bis(2-(((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-oxoethyl)acetamide

N,N-bis(2-(((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-oxoethyl)-2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)acetamide

2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide