(E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

Base Information

• Chemical Name: (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate
• CAS No.: 1346502-20-2
• Molecular Formula: C₂₇H₃₇N₅O₆
• Molecular Weight: 527.621
• Mol file: 1346502-20-2.mol

Synonyms:(E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

Chemical Property of (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

There total 9 articles about (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate (1346502-40-6) → (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate (1346502-20-2)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 3h;

DOI:10.1021/jm2009106

Reference yield:

2-choro-5-iodopyridine (69045-79-0) → (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate (1346502-20-2)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 150 °C / Microwave irradiation

2: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

3: dmap; triethylamine / dichloromethane / 0.83 h / 0 - 20 °C

4: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C

With dmap; sodium azide; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm2009106

Reference yield:

4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene (937183-61-4) → (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate (1346502-20-2)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 0.83 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C

With dmap; sodium azide; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm2009106

upstream raw materials:

2-choro-5-iodopyridine

4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene

2-(2-(2-(2-(5-iodopyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethanol

(E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

Downstream raw materials:

(E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)-N,N-bis(2-(((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-oxoethyl)acetamide

N,N-bis(2-(((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-oxoethyl)-2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)acetamide

2-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-N,N-bis(14-(5-((E)-4-(methylamino)styryl)pyridin-2-yloxy)-2-oxo-6,9,12-trioxa-3-azatetradecyl)acetamide