6-Phenyl-4-thiophen-2-yl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile

Base Information

• Chemical Name: 6-Phenyl-4-thiophen-2-yl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile
• CAS No.: 131841-88-8
• Molecular Formula: C₁₆H₁₂N₂S₂
• Molecular Weight: 296.417
• Mol file: 131841-88-8.mol

Synonyms:6-Phenyl-4-thiophen-2-yl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile

Chemical Property of 6-Phenyl-4-thiophen-2-yl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Phenyl-4-thiophen-2-yl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile

There total 1 articles about 6-Phenyl-4-thiophen-2-yl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Cyanothioacetamide (7357-70-2) + (E)-1-phenyl-3-(thiophen-2-yl)-2-propen-1-one (39511-11-0) → 6-Phenyl-4-thiophen-2-yl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile (131841-88-8)

Guidance literature:

With sodium ethanolate; In ethanol; for 2h; Ambient temperature;

Reference yield:

6-Phenyl-4-thiophen-2-yl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile (131841-88-8) → 3-cyano-6-phenyl-4-(thiophen-2'-yl)-2(1H)-pyridone (59851-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: nitrosylsulfuric acid / acetic acid; H₂O / 0.5 h / Heating

2: t-BuOK, I₂ / 2-methyl-propan-2-ol / 48 h / Heating

With nitrosylsulfuric acid; potassium tert-butylate; iodine; In water; acetic acid; tert-butyl alcohol;

Reference yield:

6-Phenyl-4-thiophen-2-yl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile (131841-88-8) → 3-cyano-6-phenyl-4-(2-thienyl)pyridin-2(1H)-thione (131841-89-9)

Guidance literature:

With nitrosylsulfuric acid; In water; acetic acid; for 0.5h; Heating;

upstream raw materials:

Cyanothioacetamide

(E)-1-phenyl-3-(thiophen-2-yl)-2-propen-1-one

Downstream raw materials:

3-cyano-6-phenyl-4-(2-thienyl)pyridin-2(1H)-thione

2-Methylsulfanyl-6-phenyl-4-thiophen-2-yl-nicotinonitrile

3-cyano-6-phenyl-4-(thiophen-2'-yl)-2(1H)-pyridone