59851-02-4Relevant academic research and scientific papers
Microwave-assisted synthesis of 2(1H)-pyridones and their glucosides as cell proliferation inhibitors
Al-Neyadi, Shaikha S.,Hassan, Ahmed H.,Abdou, Ibrahim M.
experimental part, p. 120 - 134 (2011/10/09)
A new series of substituted 2(1H)-pyridones (4a-i) and their glucosides (5, 6a-e) were prepared as potential agents against leukemia (HL-60) cells. Glucosides (5,6a-e) were synthesized using three independent methods. Microwave protocol as an ecologically
A simple and convenient synthesis of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones under solvent-free microwave conditions
Dave, Chaitanya G.,Shah, Dhaval A.,Agrawal, Yadvendra K.
, p. 885 - 887 (2007/10/03)
A rapid and efficient method for the preparation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones by the reaction between 1,3-diarylpropen-1-ones and cyanoacetamide using powdered potassium hydroxide under microwave irradiation is reported. Excellent yields and higher purity are obtained in this solvent free one pot synthesis as compared to conventional methods.
ACTIVATED NITRILES IN HETEROCYCLIC SYNTHESIS: A NOVEL SYNTHETIC ROUTE TO FURYL- AND THIENYL-SUBSTITUTED PYRIDINE DERIVATIVES
Elgemeie, Galal Eldin Hamza,Zohdi, Hussein Fouad,Sherif, Sherif Mourad
, p. 215 - 219 (2007/10/02)
A novel synthesis of 2-thio- and 2-oxo- and 2-methoxy-3-cyano-pyridine derivatives utilizing 2-furylmethylene- and 2-thienylmethylene derivatives of acetophenone and activated nitriles as starting components is described.
Malononitriles & Cyanoesters : Part VI - Synthesis of New Biologically Active Cyanopyridines
Latif, N.,Mishriky, N.,Girgis, N. S.
, p. 147 - 149 (2007/10/02)
3-(2'-Furyl)- and 3-(2'-thienyl)-acrylophenones (I) react with malononitrile in the presence of ammonium acetate to give 2-amino-3-cyano-4,6-disubstituted-pyridines (II).The latter are hydrolysed with alkali to give the corresponding nicotinamides (IV).Th
