2-[3-(2-amino-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

Base Information

• Chemical Name: 2-[3-(2-amino-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide
• CAS No.: 921598-21-2
• Molecular Formula: C₂₅H₂₈N₂O₂
• Molecular Weight: 388.51
• Mol file: 921598-21-2.mol

Synonyms:2-[3-(2-amino-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

Chemical Property of 2-[3-(2-amino-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-(2-amino-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

There total 18 articles about 2-[3-(2-amino-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.7%

2-chloro-N-{2-[3-(2-{[(4'-hydroxybiphenyl-3-yl)methyl]amino}-2-oxoethyl)phenyl]-1,1-dimethylethyl}acetamide → 2-[3-(2-amino-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide (921598-21-2)

Guidance literature:

With acetic acid; thiourea; In 2-methyl-propan-1-ol; water; for 5h; Reflux; Large scale;

Reference yield: 54.0%

2,2,2-trichloro-N-[2-(3-{[(4'-hydroxy-biphenyl-3-ylmethyl)-carbamoyl]-methyl}-phenyl)-1,1-dimethyl-ethyl]acetamide → 2-[3-(2-amino-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide (921598-21-2)

Guidance literature:

2,2,2-trichloro-N-[2-(3-{[(4'-hydroxy-biphenyl-3-ylmethyl)-carbamoyl]-methyl}-phenyl)-1,1-dimethyl-ethyl]acetamide; With trifluoroacetic acid; In dichloromethane; for 1.5h;

With ammonia; In dichloromethane; water; pH=12; Product distribution / selectivity;

Reference yield: 54.0%

tert-butyl {1-[3-(2-{[(4'-hydroxybiphenyl-3-yl)methyl]amino}-2-oxoethyl)phenyl]-2-methylpropan-2-yl}carbamate → 2-[3-(2-amino-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide (921598-21-2)

Guidance literature:

tert-butyl {1-[3-(2-{[(4'-hydroxybiphenyl-3-yl)methyl]amino}-2-oxoethyl)phenyl]-2-methylpropan-2-yl}carbamate; With trifluoroacetic acid; In dichloromethane; for 1.5h; Inert atmosphere;

With ammonia; In water; pH=12;

DOI:10.1021/op2002408

upstream raw materials:

2-[3-(2-hydroxy-2-methylpropyl)phenyl]acetic acid

3'-(aminomethyl)biphenyl-4-ol hydrochloride

ethyl 2-[3-(2-amino-2-methylpropyl)phenyl]acetate hydrogen (2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]succinate

thiourea

Downstream raw materials:

2-(3-{2-[((2R)-2-{4-benzyloxy-3-[(methylsulfonyl)amino]phenyl}-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]-2-methylpropyl}phenyl)-N-[(4'-hydroxybiphenyl-3-yl)methyl]-acetamide

2-[3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]-phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide

2-[3-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide