1-ferrocenyl-3-(trimethylsilyl)-1-phenylprop-2-yn-1-ol

Base Information

Chemical Name:1-ferrocenyl-3-(trimethylsilyl)-1-phenylprop-2-yn-1-ol
CAS No.:292626-06-3
Molecular Formula:C₂₂H₂₄FeOSi
Molecular Weight:388.364
Hs Code.:

Synonyms:1-ferrocenyl-3-(trimethylsilyl)-1-phenylprop-2-yn-1-ol

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Chemical Property of 1-ferrocenyl-3-(trimethylsilyl)-1-phenylprop-2-yn-1-ol

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Technology Process of 1-ferrocenyl-3-(trimethylsilyl)-1-phenylprop-2-yn-1-ol

There total 2 articles about 1-ferrocenyl-3-(trimethylsilyl)-1-phenylprop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1272-44-2
benzoylferrocene

: 1066-54-2
trimethylsilylacetylene

: 292626-06-3
1-ferrocenyl-3-(trimethylsilyl)-1-phenylprop-2-yn-1-ol

Guidance literature:: trimethylsilylacetylene; With n-butyllithium; In diethyl ether; at -10 ℃; Inert atmosphere;

benzoylferrocene; In diethyl ether; at -10 - 20 ℃;
DOI:10.1002/jhet.1680

Reference yield: 68.6%

: 1272-44-2
benzoylferrocene

: 1066-54-2
trimethylsilylacetylene

: 1-ferrocenyl-1-phenylprop-2-yn-1-ol

: 292626-06-3
1-ferrocenyl-3-(trimethylsilyl)-1-phenylprop-2-yn-1-ol

Guidance literature:: With n-butyllithium; In tetrahydrofuran; a Buli soln. was added at -60°C under Ar to a THF soln. of Me3SiCCH, the mixt. was alowed to warm to room temp. with stirring, FcCOPh wasadded under Ar, the mixt. was stirred at room temp. for ca. 60 h; water was added, solvents were removed in vacuo, residue dissolved in CH2Cl2, soln. was washed with aq. NaHCO3, water, dried with Na2SO4, evapd., residue was chromd. on basic alumina with 2:1 hexane-ether as eluent; elem. anal. for silylated propynol;

Reference yield: 84.3%

: 292626-06-3
1-ferrocenyl-3-(trimethylsilyl)-1-phenylprop-2-yn-1-ol

: 74-88-4
methyl iodide

: 672958-79-1
1-ferrocenyl-1-methoxy-3-trimethylsilyl-1-phenylpropyne

Guidance literature:: With methyllithium; In tetrahydrofuran; diethyl ether; an ethereal MeLi soln. was added at -60°C under Ar to a THF soln.of silylated propynol, the stirred soln. was allowed to warm to -25.deg ree.C, MeI was added, the mixt. was stirred overnight at room temp.; volatiles were removed in vacuo, residue was dissolved in ether, soln. washed with aq. NaHCO3 and water, dried over Na2SO4, evapd.; elem. anal.;