N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-N-butyl-2-iodobenzamide

Base Information

Chemical Name:N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-N-butyl-2-iodobenzamide
CAS No.:1307741-49-6
Molecular Formula:C₂₉H₂₈F₆INO₄
Molecular Weight:695.441
Hs Code.:

Synonyms:N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-N-butyl-2-iodobenzamide

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Chemical Property of N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-N-butyl-2-iodobenzamide

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Technology Process of N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-N-butyl-2-iodobenzamide

There total 4 articles about N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-N-butyl-2-iodobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1307741-41-8
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,5-dimethoxyphenyl]-2-iodobenzamide

: 100-39-0
benzyl bromide

: 1307741-49-6
N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-N-butyl-2-iodobenzamide

Guidance literature:: N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,5-dimethoxyphenyl]-2-iodobenzamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.03.002

Reference yield:

: 1307741-27-0
2-(4-butylamino-2,5-dimethoxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

: 1307741-49-6
N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-N-butyl-2-iodobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 3 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 3 h / 0 °C / Inert atmosphere

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.002

Reference yield:

: 356537-67-2
2,5-dimethoxy-N-butylaniline

: 1307741-49-6
N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl]-N-butyl-2-iodobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / toluene / 10 h / 120 °C

2.1: triethylamine / dichloromethane / 3 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

3.2: 3 h / 0 °C / Inert atmosphere

With sodium hydride; toluene-4-sulfonic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.03.002