Technology Process of 2-[4-[1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]acetic acid
There total 7 articles about 2-[4-[1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 2-[4-[1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]acetate;
With
lithium hydroxide monohydrate; water;
In
tetrahydrofuran; methanol;
at 18 - 25 ℃;
for 16h;
With
citric acid;
In
water;
at 18 - 25 ℃;
pH=4;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere
3.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 25 °C / 3750.38 Torr
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 80 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 18 - 25 °C
6.1: ammonium formate / palladium 10% on activated carbon / 78 °C
7.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 16 h / 18 - 25 °C
7.2: 18 - 25 °C / pH 4
With
lithium hydroxide monohydrate; water; hydrogen; ammonium formate; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 5%-palladium/activated carbon; palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 80 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 18 - 25 °C
3.1: ammonium formate / palladium 10% on activated carbon / 78 °C
4.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 16 h / 18 - 25 °C
4.2: 18 - 25 °C / pH 4
With
lithium hydroxide monohydrate; water; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
![ethyl 2-[4-[1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]acetate](/Databaselist/images/loading.webp)
