(3aR,5R,6R,6aR)-5-((R)-2-azido-1-(benzyloxy)ethyl)-6-(benzyloxy)-6-(2-(benzyloxy)ethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole

Base Information

Chemical Name:(3aR,5R,6R,6aR)-5-((R)-2-azido-1-(benzyloxy)ethyl)-6-(benzyloxy)-6-(2-(benzyloxy)ethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole
CAS No.:1271332-77-4
Molecular Formula:C₃₂H₃₇N₃O₆
Molecular Weight:559.662
Hs Code.:

Synonyms:(3aR,5R,6R,6aR)-5-((R)-2-azido-1-(benzyloxy)ethyl)-6-(benzyloxy)-6-(2-(benzyloxy)ethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole

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Chemical Property of (3aR,5R,6R,6aR)-5-((R)-2-azido-1-(benzyloxy)ethyl)-6-(benzyloxy)-6-(2-(benzyloxy)ethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole

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Technology Process of (3aR,5R,6R,6aR)-5-((R)-2-azido-1-(benzyloxy)ethyl)-6-(benzyloxy)-6-(2-(benzyloxy)ethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole

There total 8 articles about (3aR,5R,6R,6aR)-5-((R)-2-azido-1-(benzyloxy)ethyl)-6-(benzyloxy)-6-(2-(benzyloxy)ethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1271332-74-1
(R)-2-(benzyloxy)-2-((3aR,5R,6R,6aR)-6-(benzyloxy)-6-(2-(benzyloxy)ethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethyl methanesulfonate

: 1271332-77-4
(3aR,5R,6R,6aR)-5-((R)-2-azido-1-(benzyloxy)ethyl)-6-(benzyloxy)-6-(2-(benzyloxy)ethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 120 ℃; for 3h;
DOI:10.1016/j.tetasy.2010.11.027

Reference yield:

: 1271332-69-4
(3aR,5R,6R,6aR)-6-(benzyloxy)-5-((R)-1-(benzyloxy)-2-(trityloxy)ethyl)-6-(2-benzyloxyethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole

: 1271332-77-4
(3aR,5R,6R,6aR)-5-((R)-2-azido-1-(benzyloxy)ethyl)-6-(benzyloxy)-6-(2-(benzyloxy)ethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 3 steps

1: silica supported perchloric acid / methanol / 3 h / 20 °C

2: dmap; triethylamine / dichloromethane / 1 h / 0 °C

3: sodium azide / N,N-dimethyl-formamide / 3 h / 120 °C

With dmap; sodium azide; silica supported perchloric acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2010.11.027

Reference yield:

: 1271332-71-8
(R)-2-(benzyloxy)-2-((3aR,5R,6R,6aR)-6-(benzyloxy)-6-(2-(benzyloxy)ethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethanol

: 1271332-77-4
(3aR,5R,6R,6aR)-5-((R)-2-azido-1-(benzyloxy)ethyl)-6-(benzyloxy)-6-(2-(benzyloxy)ethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 1 h / 0 °C

2: sodium azide / N,N-dimethyl-formamide / 3 h / 120 °C

With dmap; sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2010.11.027