(S)-methyl 3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinate

Base Information

Chemical Name:(S)-methyl 3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinate
CAS No.:1439933-38-6
Molecular Formula:C₃₃H₃₂N₄O₃
Molecular Weight:532.642
Hs Code.:

Synonyms:(S)-methyl 3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinate

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Chemical Property of (S)-methyl 3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinate

Chemical Property:

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Technology Process of (S)-methyl 3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinate

There total 13 articles about (S)-methyl 3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439933-37-5
(S)-N-(1-(3-isopropylphenyl)ethyl)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-1H-benzo[d]imidazole-5-carboxamide

: 53636-56-9
methyl 3-bromopicolinate

: 1439933-38-6
(S)-methyl 3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 100 ℃; for 18h; Inert atmosphere;

Reference yield:

: 40428-87-3
1-[3-(propan-2-yl)phenyl]ethan-1-one

: 1439933-38-6
(S)-methyl 3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinate

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) isopropylate / tetrahydrofuran / 16 h / 90 °C

2: water; sodium tetrahydroborate / tetrahydrofuran / 16 h / 20 °C

3: methanol / 3 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium acetate / 2 h / 90 °C / Inert atmosphere

6: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; tetrahydrofuran; water / 18 h / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; titanium(IV) isopropylate; methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium acetate; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1439933-29-5
(S)-N-((S)-1-(3-isopropylphenyl)ethyl)-2-methylpropane-2-sulfinamide

: 1439933-38-6
(S)-methyl 3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium acetate / 2 h / 90 °C / Inert atmosphere

4: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; tetrahydrofuran; water / 18 h / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; water; N,N-dimethyl-formamide;