(S)-3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinic acid

Base Information

Chemical Name:(S)-3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinic acid
CAS No.:1439933-15-9
Molecular Formula:C₃₂H₃₀N₄O₃
Molecular Weight:518.615
Hs Code.:

Synonyms:(S)-3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinic acid

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Chemical Property of (S)-3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinic acid

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Technology Process of (S)-3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinic acid

There total 13 articles about (S)-3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439933-38-6
(S)-methyl 3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinate

: 1439933-15-9
(S)-3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinic acid

Guidance literature:: (S)-methyl 3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinate; With water; lithium hydroxide; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=7;

Reference yield:

: 40428-87-3
1-[3-(propan-2-yl)phenyl]ethan-1-one

: 1439933-15-9
(S)-3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: titanium(IV) isopropylate / tetrahydrofuran / 16 h / 90 °C

2.1: water; sodium tetrahydroborate / tetrahydrofuran / 16 h / 20 °C

3.1: methanol / 3 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5.1: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium acetate / 2 h / 90 °C / Inert atmosphere

6.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; tetrahydrofuran; water / 18 h / 100 °C / Inert atmosphere

7.1: water; lithium hydroxide / methanol / 2 h / 20 °C

7.2: pH 7

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; titanium(IV) isopropylate; methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium acetate; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1439933-29-5
(S)-N-((S)-1-(3-isopropylphenyl)ethyl)-2-methylpropane-2-sulfinamide

: 1439933-15-9
(S)-3-(4-((5-((1-(3-isopropylphenyl)ethyl)carbamoyl)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)picolinic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 3 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3.1: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium acetate / 2 h / 90 °C / Inert atmosphere

4.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; tetrahydrofuran; water / 18 h / 100 °C / Inert atmosphere

5.1: water; lithium hydroxide / methanol / 2 h / 20 °C

5.2: pH 7

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium acetate; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;