(3R,3aR,6R,6aR,9R,10R,10aR)-10-(benzyloxy)-2-methoxy-6,9-dimethyldecahydro-2Hnaphtho[8a,1-b]furan-3-ol

Base Information

Chemical Name:(3R,3aR,6R,6aR,9R,10R,10aR)-10-(benzyloxy)-2-methoxy-6,9-dimethyldecahydro-2Hnaphtho[8a,1-b]furan-3-ol
CAS No.:1341192-42-4
Molecular Formula:C₂₂H₃₂O₄
Molecular Weight:360.494
Hs Code.:

Synonyms:(3R,3aR,6R,6aR,9R,10R,10aR)-10-(benzyloxy)-2-methoxy-6,9-dimethyldecahydro-2Hnaphtho[8a,1-b]furan-3-ol

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Chemical Property of (3R,3aR,6R,6aR,9R,10R,10aR)-10-(benzyloxy)-2-methoxy-6,9-dimethyldecahydro-2Hnaphtho[8a,1-b]furan-3-ol

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Technology Process of (3R,3aR,6R,6aR,9R,10R,10aR)-10-(benzyloxy)-2-methoxy-6,9-dimethyldecahydro-2Hnaphtho[8a,1-b]furan-3-ol

There total 10 articles about (3R,3aR,6R,6aR,9R,10R,10aR)-10-(benzyloxy)-2-methoxy-6,9-dimethyldecahydro-2Hnaphtho[8a,1-b]furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67-56-1
methanol

: 1341192-41-3
(1R,2R,4aR,5R,7aR,7bR,10aR,11aR)-1-(benzyloxy)-2,5,9,9-tetramethyldecahydro-1Hnaphtho[1',8a':4,5]furo[2,3-d][1,3]dioxole

: 1341192-42-4
(3R,3aR,6R,6aR,9R,10R,10aR)-10-(benzyloxy)-2-methoxy-6,9-dimethyldecahydro-2Hnaphtho[8a,1-b]furan-3-ol

Guidance literature:: With hydrogenchloride; water; at 50 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ol202562w

Reference yield:

: 1341192-40-2
(1R,2R,4aR,5R,7aR,7bR,10aR,11aR)-2,5,9,9-tetramethyldecahydro-1Hnaphtho[1',8a':4,5]furo[2,3-d][1,3]dioxol-1-ol

: 1341192-42-4
(3R,3aR,6R,6aR,9R,10R,10aR)-10-(benzyloxy)-2-methoxy-6,9-dimethyldecahydro-2Hnaphtho[8a,1-b]furan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / Reflux

1.2: 1 h

2.1: hydrogenchloride; water / 0.5 h / 50 °C / Inert atmosphere

With hydrogenchloride; water; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ol202562w

Reference yield:

: 1341192-38-8
(2R,4aR,7aR,7bR,10aR,11aR)-2,5,9,9-tetramethyl-2,3,4,4a,7,7a,7b,10a-octahydro-1Hnaphtho[1',8a':4,5]furo[2,3-d][1,3]dioxol-1-one

: 1341192-42-4
(3R,3aR,6R,6aR,9R,10R,10aR)-10-(benzyloxy)-2-methoxy-6,9-dimethyldecahydro-2Hnaphtho[8a,1-b]furan-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

2.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 1 h / Reflux

3.2: 1 h

4.1: hydrogenchloride; water / 0.5 h / 50 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; water; hydrogen; sodium hydride; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/ol202562w