(S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid

Base Information

• Chemical Name: (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid
• CAS No.: 102045-96-5
• Molecular Formula: C6H10 O4
• Molecular Weight: 146.143
• Mol file: 102045-96-5.mol

Synonyms:1,3-Dioxolane-4-carboxylicacid, 2,2-dimethyl-, (S)-; (4S)-2,2-Dimethyl-1,3-dioxolan-4-carboxylic acid;(4S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid;(S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid;(S)-2,2-Dimethyldioxolane-4-carboxylic acid;(S)-2,3-(Isopropylidenedioxy)propionic acid

Chemical Property of (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid

Chemical Property:

• Vapor Pressure: 0.01mmHg at 25°C
• Boiling Point: 244.151°C at 760 mmHg
• Flash Point: 101.605°C
• PSA: 55.76000
• Density: 1.203g/cm³
• LogP: 0.22250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid

There total 8 articles about (S)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (60456-21-5) → 2,3-O-isopropylidene-L-glyceric acid (102045-96-5,62075-55-2)

Guidance literature:

With lithium hydroxide monohydrate; In methanol; at 20 ℃; for 16h;

Reference yield: 89.0%

potassium (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (117205-81-9) → 2,3-O-isopropylidene-L-glyceric acid (102045-96-5,62075-55-2)

Guidance literature:

With phosphoric acid; In ethyl acetate; at 0 ℃; pH 2;

DOI:10.1021/jm00105a060

Reference yield: 70.0%

1,2-O-isopropylidene-D-glycerol (14347-78-5,36543-79-0) → 2,3-O-isopropylidene-L-glyceric acid (102045-96-5,62075-55-2)

Guidance literature:

With sodium hydroxide; potassium permanganate;

DOI:10.1080/00397919508011831

upstream raw materials:

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

potassium (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

1,2-O-isopropylidene-D-glycerol

Downstream raw materials:

(2S)-2,3-isopropylideneglyceryl chloride

(S)-2,2-Dimethyl-[1,3]dioxolane-4-carboxylic acid amide

methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

(1'R,2'S,4''R)-3-[1'-formyl-4'-(2'',2''-dimethyl-[1'',3'']dioxolan-4''-yl)-3'-methyl-2'-triethylsilanyloxymethylcyclohex-3'-enyl]propionitrile