(S)-dibenzyl 1-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)hydrazine-1,2-dicarboxylate

Base Information

Chemical Name:(S)-dibenzyl 1-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)hydrazine-1,2-dicarboxylate
CAS No.:952685-60-8
Molecular Formula:C₂₄H₃₀N₂O₆
Molecular Weight:442.512
Hs Code.:

Synonyms:(S)-dibenzyl 1-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)hydrazine-1,2-dicarboxylate

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Chemical Property of (S)-dibenzyl 1-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)hydrazine-1,2-dicarboxylate

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Technology Process of (S)-dibenzyl 1-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)hydrazine-1,2-dicarboxylate

There total 4 articles about (S)-dibenzyl 1-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 952685-59-5
3-(tetrahydro-2H-pyran-4-yl)propanal

: 2449-05-0
dibenzyl azodicarboxylate

: 952685-60-8
(S)-dibenzyl 1-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: 3-(tetrahydro-2H-pyran-4-yl)propanal; dibenzyl azodicarboxylate; With D-Prolin; In acetonitrile; at 0 ℃; for 15h;

With sodium tetrahydroborate; In ethanol; acetonitrile; at 0 ℃; for 0.666667h;

With citric acid; In ethanol; water; acetonitrile;

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 952685-60-8
(S)-dibenzyl 1-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: hydrogen / palladium hydroxide on carbon / methanol

3.1: Dess-Martin periodane / dichloromethane / 20 °C

4.1: D-Prolin / acetonitrile / 15 h / 0 °C

4.2: 0.67 h / 0 °C

With n-butyllithium; hydrogen; Dess-Martin periodane; D-Prolin; palladium hydroxide on carbon; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 133243-97-7
3-(tetrahydro-4H-pyran-4-ylidene)propan-1-ol

: 952685-60-8
(S)-dibenzyl 1-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium hydroxide on carbon / methanol

2.1: Dess-Martin periodane / dichloromethane / 20 °C

3.1: D-Prolin / acetonitrile / 15 h / 0 °C

3.2: 0.67 h / 0 °C

With hydrogen; Dess-Martin periodane; D-Prolin; palladium hydroxide on carbon; In methanol; dichloromethane; acetonitrile;