2-{[4-hydroxy-8-(trifluoromethyl)quinoline-3-yl]carbonyl}-N-(4-methoxyphenyl)hydrazinecarbothioamide

Base Information

Chemical Name:2-{[4-hydroxy-8-(trifluoromethyl)quinoline-3-yl]carbonyl}-N-(4-methoxyphenyl)hydrazinecarbothioamide
CAS No.:1346226-52-5
Molecular Formula:C₁₉H₁₅F₃N₄O₃S
Molecular Weight:436.414
Hs Code.:

Synonyms:2-{[4-hydroxy-8-(trifluoromethyl)quinoline-3-yl]carbonyl}-N-(4-methoxyphenyl)hydrazinecarbothioamide

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Chemical Property of 2-{[4-hydroxy-8-(trifluoromethyl)quinoline-3-yl]carbonyl}-N-(4-methoxyphenyl)hydrazinecarbothioamide

Chemical Property:

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Technology Process of 2-{[4-hydroxy-8-(trifluoromethyl)quinoline-3-yl]carbonyl}-N-(4-methoxyphenyl)hydrazinecarbothioamide

There total 4 articles about 2-{[4-hydroxy-8-(trifluoromethyl)quinoline-3-yl]carbonyl}-N-(4-methoxyphenyl)hydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 873942-91-7
4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide

: 2284-20-0
4-Methoxyphenyl isothiocyanate

: 1346226-52-5
2-{[4-hydroxy-8-(trifluoromethyl)quinoline-3-yl]carbonyl}-N-(4-methoxyphenyl)hydrazinecarbothioamide

Guidance literature:: With pyridine; In ethanol; for 3h; Reflux;
DOI:10.1016/j.ejmech.2011.07.033

Reference yield:

: 23779-94-4
2-[(2-trifluoromethylphenylamino)methylene]malonic acid diethyl ester

: 1346226-52-5
2-{[4-hydroxy-8-(trifluoromethyl)quinoline-3-yl]carbonyl}-N-(4-methoxyphenyl)hydrazinecarbothioamide

Guidance literature:: Multi-step reaction with 3 steps

1: Dowtherm medium / 4 h / 250 °C

2: hydrazine hydrate / ethanol / 2.5 h / Reflux

3: pyridine / ethanol / 3 h / Reflux

With pyridine; hydrazine hydrate; In ethanol; Dowtherm medium;
DOI:10.1016/j.ejmech.2011.07.033

Reference yield:

: 23851-84-5
4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester

: 1346226-52-5
2-{[4-hydroxy-8-(trifluoromethyl)quinoline-3-yl]carbonyl}-N-(4-methoxyphenyl)hydrazinecarbothioamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 2.5 h / Reflux

2: pyridine / ethanol / 3 h / Reflux

With pyridine; hydrazine hydrate; In ethanol;
DOI:10.1016/j.ejmech.2011.07.033