(4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-2-((1R,2R)-2-vinyl-cyclopropyl)-[1,3,2]dioxaborolane

Base Information

Chemical Name:(4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-2-((1R,2R)-2-vinyl-cyclopropyl)-[1,3,2]dioxaborolane
CAS No.:615574-37-3
Molecular Formula:C₃₅H₃₅BO₄
Molecular Weight:530.471
Hs Code.:

Synonyms:(4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-2-((1R,2R)-2-vinyl-cyclopropyl)-[1,3,2]dioxaborolane

Suppliers and Price of (4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-2-((1R,2R)-2-vinyl-cyclopropyl)-[1,3,2]dioxaborolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-2-((1R,2R)-2-vinyl-cyclopropyl)-[1,3,2]dioxaborolane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Useful:

Technology Process of (4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-2-((1R,2R)-2-vinyl-cyclopropyl)-[1,3,2]dioxaborolane

There total 3 articles about (4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-2-((1R,2R)-2-vinyl-cyclopropyl)-[1,3,2]dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 321882-79-5
(1R,2R)-2-[(4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-[1,3,2]dioxaborolan-2-yl]-cyclopropanecarbaldehyde

: 615574-37-3
(4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-2-((1R,2R)-2-vinyl-cyclopropyl)-[1,3,2]dioxaborolane

Guidance literature:: Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 1h; Inert atmosphere;

(1R,2R)-2-[(4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-[1,3,2]dioxaborolan-2-yl]-cyclopropanecarbaldehyde; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 15h; Inert atmosphere;
DOI:10.1002/ejoc.200900414

Reference yield: 81.0%

: 19493-09-5
Methylenetriphenylphosphorane

: 321882-79-5
(1R,2R)-2-[(4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-[1,3,2]dioxaborolan-2-yl]-cyclopropanecarbaldehyde

: 615574-37-3
(4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-2-((1R,2R)-2-vinyl-cyclopropyl)-[1,3,2]dioxaborolane

Guidance literature:: In tetrahydrofuran; Wittig reaction for 3 h at 0°C;
DOI:10.1016/S0022-328X(03)00403-0

Reference yield:

: 321882-78-4
(4R,5R,1'R,2'R)-2-[2-(hydroxymethyl)cyclopropyl]-4,5-bis[methoxy(diphenyl)methyl]-1,3,2-dioxaborolane

: 615574-37-3
(4R,5R)-4,5-Bis-(methoxy-diphenyl-methyl)-2-((1R,2R)-2-vinyl-cyclopropyl)-[1,3,2]dioxaborolane

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NMO; TPAP / CH₂Cl₂ / 0 - 20 °C

2: 80 percent / tetrahydrofuran / 3 h / 0 °C

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; In tetrahydrofuran; dichloromethane; 2: Wittig reaction;
DOI:10.1016/S0022-328X(03)00403-0