N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-prolin-4-one ethyl ester

Base Information

• Chemical Name: N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-prolin-4-one ethyl ester
• CAS No.: 103580-24-1
• Molecular Formula: C₂₅H₃₁Cl₃N₂O₈
• Molecular Weight: 593.889

Synonyms:N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-prolin-4-one ethyl ester

Chemical Property of N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-prolin-4-one ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-prolin-4-one ethyl ester

There total 4 articles about N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-prolin-4-one ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-4-hydroxyproline ethyl ester (103654-87-1) → N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-prolin-4-one ethyl ester (103580-24-1)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 72h; Ambient temperature;

DOI:10.1021/jm00168a013

Reference yield:

N-[N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanyl]-4-hydroxy-L-proline ethyl ester + pyridinium chlorochromate (PCC) → N-[N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanyl]-L-prolin-4-one ethyl ester (103580-24-1)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane;

Reference yield:

N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine (92893-50-0) → N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-prolin-4-one ethyl ester (103580-24-1)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 3.5 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / Ambient temperature

3: 95 percent / pyridinium chlorochromate / CH₂Cl₂ / 72 h / Ambient temperature

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; pyridinium chlorochromate; In dichloromethane;

DOI:10.1021/jm00168a013

upstream raw materials:

N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-4-hydroxyproline ethyl ester

N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine

(S)-2-[((S)-1-Chlorocarbonyl-ethyl)-(2,2,2-trichloro-ethoxycarbonyl)-amino]-4-phenyl-butyric acid ethyl ester

Downstream raw materials:

1'--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide

N-[N'-((1S)-1-carboxy-3-phenylpropyl)-L-alanyl]-4-[N²-(3-sulfamyl-4-chlorobenzoyl)hydrazino]-L-proline

N--L-alanyl>-(4RS)-4--N-methylamino>-L-proline S,S-dioxide

1'-[N'-((1S)-1-carboxy-3-phenylpropyl)-L-alanyl]-5'-carboxy-7-(aminosulfonyl)-6-chlorospiro(2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine) S,S-dioxide

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