4-benzoyl-2-chloronicotinonitrile

Base Information

• Chemical Name: 4-benzoyl-2-chloronicotinonitrile
• CAS No.: 1194341-12-2
• Molecular Formula: C₁₃H₇ClN₂O
• Molecular Weight: 242.664
• Mol file: 1194341-12-2.mol

Synonyms:4-benzoyl-2-chloronicotinonitrile

Chemical Property of 4-benzoyl-2-chloronicotinonitrile

Chemical Property:

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Technology Process of 4-benzoyl-2-chloronicotinonitrile

There total 1 articles about 4-benzoyl-2-chloronicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + benzoyl chloride (98-88-4) → 4-benzoyl-2-chloronicotinonitrile (1194341-12-2)

Guidance literature:

2-chloro-3-pyridinecarbonitrile; With (2,2,6,6-tetramethylpiperidyl)2Mn*2MgCl₂*4LiCl; In tetrahydrofuran; at 0 ℃; for 0.75h; Inert atmosphere;

benzoyl chloride; With copper(I) cyanide di(lithium chloride); In tetrahydrofuran; at -30 - 0 ℃; chemospecific reaction; Inert atmosphere;

DOI:10.1002/anie.200903505

upstream raw materials:

2-chloro-3-pyridinecarbonitrile

benzoyl chloride

Refernces