Ozagrel methylester

Base Information

• Chemical Name: Ozagrel methylester
• CAS No.: 866157-50-8
• Molecular Formula: C13H12 N2 O2
• Molecular Weight: 228.25
• Mol file: 866157-50-8.mol

Synonyms:Ozagrel methylester;

Chemical Property of Ozagrel methylester

Chemical Property:

• Vapor Pressure: 1.17E-07mmHg at 25°C
• Boiling Point: 431.8°C at 760 mmHg
• PKA: 5.42±0.10(Predicted)
• Flash Point: 214.9°C
• PSA: 44.12000
• Density: 1.1g/cm³
• LogP: 2.11760
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Methyl3-(4-(1H-imidazol-1-yl)phenyl)acrylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ozagrel methylester

There total 1 articles about Ozagrel methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethyl phosphonoacetate (5927-18-4) + 1-(4-formylphenyl)-1H-imidazole (10040-98-9) → methyl 3-[4-(1H-imidazol-1-yl)phenyl]acrylate (866157-50-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran;

Reference yield: 90.0%

methyl 3-[4-(1H-imidazol-1-yl)phenyl]acrylate (866157-50-8) + 1,3,5-Tris(bromomethyl)benzene (18226-42-1) → C48H45N6O6(3+)*3F6P(1-)

Guidance literature:

methyl 3-[4-(1H-imidazol-1-yl)phenyl]acrylate; 1,3,5-Tris(bromomethyl)benzene; In N,N-dimethyl-formamide; at 110 ℃; for 24h; Inert atmosphere; Schlenk technique;

With ammonium hexafluorophosphate; In methanol; at 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201713240

Reference yield: 80.0%

methyl 3-[4-(1H-imidazol-1-yl)phenyl]acrylate (866157-50-8) + 1,3,5-tris(bromomethyl)-2,4,6-trimethylbenzene (21988-87-4) → C51H51N6O6(3+)*3F6P(1-)

Guidance literature:

methyl 3-[4-(1H-imidazol-1-yl)phenyl]acrylate; 1,3,5-tris(bromomethyl)-2,4,6-trimethylbenzene; In N,N-dimethyl-formamide; at 110 ℃; for 24h; Inert atmosphere; Schlenk technique;

With ammonium hexafluorophosphate; In methanol; at 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201713240

upstream raw materials:

trimethyl phosphonoacetate

1-(4-formylphenyl)-1H-imidazole