N-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)-N-methylacetamide

Base Information

Chemical Name:N-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)-N-methylacetamide
CAS No.:1402796-87-5
Molecular Formula:C₃₁H₃₄F₆N₂O₄
Molecular Weight:612.612
Hs Code.:

N-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)-N-methylacetamide

Synonyms:N-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)-N-methylacetamide

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Chemical Property of N-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)-N-methylacetamide

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Technology Process of N-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)-N-methylacetamide

There total 9 articles about N-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1402796-85-3
N-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)acetamide

: 74-88-4
methyl iodide

: 1402796-87-5
N-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)-N-methylacetamide

Guidance literature:: N-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)acetamide; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

: 4255-62-3
4,4-dimethylcyclohexane-1-one

: 1402796-87-5
N-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: phosphorus tribromide / dichloromethane

2.1: sodium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / 1,2-dimethoxyethane; water / Microwave irradiation

3.1: nitric acid; acetic acid

4.1: sodium cyanoborohydride; acetic acid / dichloromethane

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane

6.1: methanol / Raney Ni

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

8.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

8.2: 3 h / 0 - 20 °C

With methanol; nitric acid; phosphorus tribromide; sodium hydride; sodium cyanoborohydride; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 2.1: Suzuki Coupling;

Reference yield:

: 1053265-66-9
2-bromo-5,5'-bis-methylcyclohex-1-enylcarbaldehyde

: 1402796-87-5
N-(3-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4-methoxyphenyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / 1,2-dimethoxyethane; water / Microwave irradiation

2.1: nitric acid; acetic acid

3.1: sodium cyanoborohydride; acetic acid / dichloromethane

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane

5.1: methanol / Raney Ni

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

7.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

7.2: 3 h / 0 - 20 °C

With methanol; nitric acid; sodium hydride; sodium cyanoborohydride; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 1.1: Suzuki Coupling;