methyl 2-(4-methyl-2-(2-(4-oxo-3-phenyl-3,4-dihydro quinazolin-2-ylthio)acetamido)pentanamido)acetate

Base Information

Chemical Name:methyl 2-(4-methyl-2-(2-(4-oxo-3-phenyl-3,4-dihydro quinazolin-2-ylthio)acetamido)pentanamido)acetate
CAS No.:1638842-92-8
Molecular Formula:C₂₅H₂₈N₄O₅S
Molecular Weight:496.587
Hs Code.:

Synonyms:methyl 2-(4-methyl-2-(2-(4-oxo-3-phenyl-3,4-dihydro quinazolin-2-ylthio)acetamido)pentanamido)acetate

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Chemical Property of methyl 2-(4-methyl-2-(2-(4-oxo-3-phenyl-3,4-dihydro quinazolin-2-ylthio)acetamido)pentanamido)acetate

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Technology Process of methyl 2-(4-methyl-2-(2-(4-oxo-3-phenyl-3,4-dihydro quinazolin-2-ylthio)acetamido)pentanamido)acetate

There total 7 articles about methyl 2-(4-methyl-2-(2-(4-oxo-3-phenyl-3,4-dihydro quinazolin-2-ylthio)acetamido)pentanamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₂N₆O₃S

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 1638842-92-8
methyl 2-(4-methyl-2-(2-(4-oxo-3-phenyl-3,4-dihydro quinazolin-2-ylthio)acetamido)pentanamido)acetate

Guidance literature:: With triethylamine; In ethyl acetate; at -5 - 25 ℃; for 48h;
DOI:10.1248/cpb.c14-00158

Reference yield:

: 18741-24-7
3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

: 1638842-92-8
methyl 2-(4-methyl-2-(2-(4-oxo-3-phenyl-3,4-dihydro quinazolin-2-ylthio)acetamido)pentanamido)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / ethanol / 2 h / 25 °C

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / acetonitrile / 10 h / -5 - 20 °C

3: hydrazine hydrate / methanol / 4 h / 78 °C

4: hydrogenchloride; sodium nitrite / water; acetic acid / 1 h / -5 °C

5: triethylamine / ethyl acetate / 48 h / -5 - 25 °C

With hydrogenchloride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; sodium nitrite; In methanol; ethanol; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1248/cpb.c14-00158

Reference yield:

: 30530-97-3
2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)acetic acid

: 1638842-92-8
methyl 2-(4-methyl-2-(2-(4-oxo-3-phenyl-3,4-dihydro quinazolin-2-ylthio)acetamido)pentanamido)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / acetonitrile / 10 h / -5 - 20 °C

2: hydrazine hydrate / methanol / 4 h / 78 °C

3: hydrogenchloride; sodium nitrite / water; acetic acid / 1 h / -5 °C

4: triethylamine / ethyl acetate / 48 h / -5 - 25 °C

With hydrogenchloride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; sodium nitrite; In methanol; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1248/cpb.c14-00158