tert-butyl 5-bromo-3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

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Chemical Name:tert-butyl 5-bromo-3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
CAS No.:1350325-29-9
Molecular Formula:C₂₁H₁₉BrClF₃N₂O₃
Molecular Weight:520.738
Hs Code.:

Synonyms:tert-butyl 5-bromo-3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

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Chemical Property of tert-butyl 5-bromo-3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

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Technology Process of tert-butyl 5-bromo-3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

There total 11 articles about tert-butyl 5-bromo-3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 383-62-0
ethyl 2-chloro-2,2-difluoroacetate

: 1350325-30-2
tert-butyl 5-bromo-3-[(1S)-1-(2-chloro-3-fluoro-6-hydroxyphenyl)(1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

: 1350325-29-9
tert-butyl 5-bromo-3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 4h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1350325-29-9
tert-butyl 5-bromo-3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 0 - 20 °C

2: piperidine / dichloromethane / 32 °C

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C

With piperidine; sodium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1350325-29-9
tert-butyl 5-bromo-3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / methanol / 12 h / 20 °C

2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.5 h / -60 °C

2.2: -60 - 45 °C / Inert atmosphere

3.1: ChiralPak IA / carbon dioxide; methanol / Resolution of racemate

4.1: boron tribromide / dichloromethane / 18.16 h / -78 - 20 °C

4.2: 0.5 h / 0 - 20 °C

5.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

6.1: piperidine / dichloromethane / 32 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C

With piperidine; boron trifluoride diethyl etherate; boron tribromide; sodium hydride; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; carbon dioxide; N,N-dimethyl-formamide;