*,R^*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

Base Information

• Chemical Name: *,R^*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester
• CAS No.: 95924-70-2
• Molecular Formula: C₁₈H₂₆N₂O₄
• Molecular Weight: 334.415

Synonyms:*,R^*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

Chemical Property of *,R^*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

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Technology Process of *,R^*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

There total 6 articles about *,R^*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-valinol (2026-48-4,473-75-6) + N-Benzyloxycarbonyl-L-proline (1148-11-4) → *,R*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester (95924-70-2)

Guidance literature:

With 4-methyl-morpholine; chloroformic acid ethyl ester; In ethyl acetate; at -15 - 20 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1055/s-0033-1340215

Reference yield: 86.0%

(R)-2-amino-3-methylbutanol (4276-09-9,473-75-6) + (S)-benzyloxycarbonyl-proline acid chloride (61350-60-5,61350-62-7,89705-40-8,106709-50-6) → *,R*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester (95924-70-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1016/j.tet.2004.02.038

Reference yield:

(S)-valinol (2026-48-4,473-75-6) + Z-proline N-hydroxysuccinimide ester (3397-33-9) → *,R*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester (95924-70-2)

Guidance literature:

With triethylamine; In 1,2-dimethoxyethane; ethyl acetate; acetone;

upstream raw materials:

(S)-valinol

N-Benzyloxycarbonyl-L-proline

(R)-2-amino-3-methylbutanol

(S)-benzyloxycarbonyl-proline acid chloride

Downstream raw materials:

*,R^*)>-2-<<<1-Formyl-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

(2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester

N-<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-2-pyrrolidinecarboxamide

2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-(ethoxy-4-oxobutyl)>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

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