(E)-(R)-3-Hydroxy-2,4,6,8-tetramethyl-non-4-enoic acid (3-hydroxy-5-methoxy-phenyl)-amide

Base Information

• Chemical Name: (E)-(R)-3-Hydroxy-2,4,6,8-tetramethyl-non-4-enoic acid (3-hydroxy-5-methoxy-phenyl)-amide
• CAS No.: 911030-83-6
• Molecular Formula: C₂₀H₃₁NO₄
• Molecular Weight: 349.47
• Mol file: 911030-83-6.mol

Synonyms:(E)-(R)-3-Hydroxy-2,4,6,8-tetramethyl-non-4-enoic acid (3-hydroxy-5-methoxy-phenyl)-amide

Chemical Property of (E)-(R)-3-Hydroxy-2,4,6,8-tetramethyl-non-4-enoic acid (3-hydroxy-5-methoxy-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(R)-3-Hydroxy-2,4,6,8-tetramethyl-non-4-enoic acid (3-hydroxy-5-methoxy-phenyl)-amide

There total 5 articles about (E)-(R)-3-Hydroxy-2,4,6,8-tetramethyl-non-4-enoic acid (3-hydroxy-5-methoxy-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(E)-(R)-3-Hydroxy-2,4,6,8-tetramethyl-non-4-enoic acid (911030-79-0) + 3-amino-5-methoxyphenol (162155-27-3) → (E)-(R)-3-Hydroxy-2,4,6,8-tetramethyl-non-4-enoic acid (3-hydroxy-5-methoxy-phenyl)-amide (911030-83-6)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2006.06.158

Reference yield:

(E)-(R)-2,4,6-Trimethyl-hept-2-enal (911030-82-5) → (E)-(R)-3-Hydroxy-2,4,6,8-tetramethyl-non-4-enoic acid (3-hydroxy-5-methoxy-phenyl)-amide (911030-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C

2: 96 percent / WSCI*HCl / CH₂Cl₂ / 2 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2006.06.158

Reference yield:

(E)-(R)-2,4,6-Trimethyl-hept-2-en-1-ol (911030-81-4) → (E)-(R)-3-Hydroxy-2,4,6,8-tetramethyl-non-4-enoic acid (3-hydroxy-5-methoxy-phenyl)-amide (911030-83-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / MnO₂ / hexane / 12 h / 40 °C

2: 70 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C

3: 96 percent / WSCI*HCl / CH₂Cl₂ / 2 h / 20 °C

With manganese(IV) oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1016/j.tetlet.2006.06.158

upstream raw materials:

(E)-(R)-3-Hydroxy-2,4,6,8-tetramethyl-non-4-enoic acid

3-amino-5-methoxyphenol

(E)-(R)-2,4,6-Trimethyl-hept-2-enal

(E)-(R)-2,4,6-Trimethyl-hept-2-en-1-ol

Downstream raw materials:

(E)-(R)-2,4,6,8-Tetramethyl-3-oxo-non-4-enoic acid (3-methoxy-5,6-dioxo-cyclohexa-1,3-dienyl)-amide