3-Amino-5-methoxyphenol

Base Information

• Chemical Name: 3-Amino-5-methoxyphenol
• CAS No.: 162155-27-3
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• European Community (EC) Number: 819-074-8
• Nikkaji Number: J2.347.343G
• Mol file: 162155-27-3.mol

Synonyms:3-amino-5-methoxyphenol;162155-27-3;3-amino-5-methoxy-phenol;SCHEMBL1794250;ILTCFIIXWWUIPC-UHFFFAOYSA-N;3-HYDROXY-5-METHOXYANILINE;MFCD16998718;AKOS006338178;MB25612;BS-16074;CS-0186761;FT-0756736;D83696;EN300-115802;Z1203579402

Chemical Property of 3-Amino-5-methoxyphenol

Chemical Property:

• Boiling Point: 332.0±22.0 °C(Predicted)
• PKA: 9?+-.0.10(Predicted)
• PSA: 55.48000
• Density: 1.219±0.06 g/cm3(Predicted)
• LogP: 1.56420
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

99% ^*data from raw suppliers

3-amino-5-methoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)O)N

Technology Process of 3-Amino-5-methoxyphenol

There total 1 articles about 3-Amino-5-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3.5-dimethoxyaniline (10272-07-8) → 3-amino-5-methoxyphenol (162155-27-3)

Guidance literature:

With sodium hydroxide; 1-dodecylthiol; In 1-methyl-pyrrolidin-2-one; at 160 ℃; for 1h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.8b00913

Reference yield: 95.0%

methyl [(4-chloroquinolin-6-yl)(methyl)oxido-λ4-sulphanylidene]carbamate (1161837-93-9) + 3-amino-5-methoxyphenol (162155-27-3) → S-[4-(3-hydroxy-5-methoxyphenyl-1-yl)-aminoquinolin-6-yl]-N-methoxy-carbonyl-S-methylsulphoximide (1161837-81-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 80 ℃; for 6h;

Reference yield: 89.0%

ethyl 2-phenylacetoacetate (5413-05-8) + 3-amino-5-methoxyphenol (162155-27-3) → 5-hydroxy-7-methoxy-4-methyl-3-phenylquinolin-2(1H)-one (1392191-15-9)

Guidance literature:

In chlorobenzene; at 160 ℃; for 0.5h; Microwave irradiation;

DOI:10.1002/cmdc.201200551

upstream raw materials:

3.5-dimethoxyaniline

Downstream raw materials:

3-isopropoxy-5-methoxy-phenylamine

(E)-(R)-3-Hydroxy-2,4,6,8-tetramethyl-non-4-enoic acid (3-hydroxy-5-methoxy-phenyl)-amide

3-iodo-5-methoxyphenol

1-iodo-3-methoxy-5-phenoxybenzene