(+/-)-2-{3,5-dichloro-4-[2-oxo-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-acetamide

Base Information

Chemical Name:(+/-)-2-{3,5-dichloro-4-[2-oxo-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-acetamide
CAS No.:955407-18-8
Molecular Formula:C₂₀H₂₂Cl₂N₄O₃
Molecular Weight:437.326
Hs Code.:

Synonyms:(+/-)-2-{3,5-dichloro-4-[2-oxo-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-acetamide

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Chemical Property of (+/-)-2-{3,5-dichloro-4-[2-oxo-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-acetamide

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Technology Process of (+/-)-2-{3,5-dichloro-4-[2-oxo-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-acetamide

There total 11 articles about (+/-)-2-{3,5-dichloro-4-[2-oxo-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 683-57-8
bromo-acetic acid amide

: 955406-07-2
3-(2,6-Dichloro-4-hydroxy-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

: 955407-18-8
(+/-)-2-{3,5-dichloro-4-[2-oxo-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-acetamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 955407-18-8
(+/-)-2-{3,5-dichloro-4-[2-oxo-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 17 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - -67 °C

2.2: 3 h / -78 °C

3.1: water; toluene-4-sulfonic acid / acetone / 24 h / 20 °C

3.2: 1 h / 45 °C

4.1: triethylamine / 140 °C

5.1: hydrazine / ethanol / 72 h / 20 °C

6.1: boron tribromide / dichloromethane / 28.5 h / 0 - 20 °C

6.2: 0.25 h / 0 °C

6.3: pH 7

7.1: caesium carbonate / N,N-dimethyl-formamide / 17 h / 20 °C

With water; boron tribromide; sodium tris(acetoxy)borohydride; caesium carbonate; toluene-4-sulfonic acid; triethylamine; hydrazine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 911724-19-1
3-(2,6-dichloro-4-methoxy-benzyl)-1-(4-oxo-cyclohexyl)-pyrrolidin-2-one

: 955407-18-8
(+/-)-2-{3,5-dichloro-4-[2-oxo-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 140 °C

2.1: hydrazine / ethanol / 72 h / 20 °C

3.1: boron tribromide / dichloromethane / 28.5 h / 0 - 20 °C

3.2: 0.25 h / 0 °C

3.3: pH 7

4.1: caesium carbonate / N,N-dimethyl-formamide / 17 h / 20 °C

With boron tribromide; caesium carbonate; triethylamine; hydrazine; In ethanol; dichloromethane; N,N-dimethyl-formamide;