C₃₀H₃₄F₂N₆O₄S

Base Information

• Chemical Name: C₃₀H₃₄F₂N₆O₄S
• CAS No.: 1383715-63-6
• Molecular Formula: C₃₀H₃₄F₂N₆O₄S
• Molecular Weight: 612.701
• Mol file: 1383715-63-6.mol

Synonyms:C₃₀H₃₄F₂N₆O₄S

Chemical Property of C₃₀H₃₄F₂N₆O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₃₄F₂N₆O₄S

There total 15 articles about C₃₀H₃₄F₂N₆O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-({(3aR,4S,6R,6aS)-6-[7-{[[N-(IR,2S)-2-(3,4-difluorophenyl)-cyclopropan-1-yl]-N-benzyl]amino}-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl}oxy)ethanol (1383715-62-5) → C30H34F2N6O4S (1383715-63-6)

Guidance literature:

2-({(3aR,4S,6R,6aS)-6-[7-{[[N-(IR,2S)-2-(3,4-difluorophenyl)-cyclopropan-1-yl]-N-benzyl]amino}-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl}oxy)ethanol; With hydrogenchloride; water; In methanol; at 20 - 25 ℃; for 5h;

With potassium carbonate; In water; toluene; at 25 - 30 ℃; pH=10;

Reference yield:

tert-butyl [[(3aR,4S,6R,6aS)-6-(N,N-dibenzylamino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy]acetate (1383715-56-7) → C30H34F2N6O4S (1383715-63-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: diisobutylaluminium hydride / toluene / 2.5 h / -25 - -20 °C

1.2: 0.25 h

2.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 10 h / 20 - 25 °C / 2327.23 Torr / Autoclave; Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 - 25 °C

4.1: sodium hydrogencarbonate; sodium dithionite / water; acetone / 2 h / 20 - 25 °C

5.1: sodium azide; acetic acid / toluene; water / 1 h / 5 - 10 °C

6.1: iodine / acetone / 2 h / 25 - 60 °C

7.1: potassium carbonate / acetone / 20 h / 55 - 60 °C

8.1: hydrogenchloride; water / methanol / 5 h / 20 - 25 °C

8.2: 25 - 30 °C / pH 10

With hydrogenchloride; sodium azide; sodium dithionite; water; hydrogen; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; water; acetone; toluene;

Reference yield:

(3aR,4S,6R,6aS)-6-(N,N-dibenzylamino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol (1383715-55-6) → C30H34F2N6O4S (1383715-63-6)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sodium t-butanolate / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / -10 - 5 °C

2.1: diisobutylaluminium hydride / toluene / 2.5 h / -25 - -20 °C

2.2: 0.25 h

3.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 10 h / 20 - 25 °C / 2327.23 Torr / Autoclave; Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 - 25 °C

5.1: sodium hydrogencarbonate; sodium dithionite / water; acetone / 2 h / 20 - 25 °C

6.1: sodium azide; acetic acid / toluene; water / 1 h / 5 - 10 °C

7.1: iodine / acetone / 2 h / 25 - 60 °C

8.1: potassium carbonate / acetone / 20 h / 55 - 60 °C

9.1: hydrogenchloride; water / methanol / 5 h / 20 - 25 °C

9.2: 25 - 30 °C / pH 10

With hydrogenchloride; sodium azide; sodium dithionite; water; hydrogen; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; toluene;

upstream raw materials:

4,6-dihydroxy-2-(propylsulfanyl)pyrimidine

4,6-dihydroxy-5-nitro-2-(propylthio)pyrimidine

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine

(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

Downstream raw materials:

ticagrelor