Technology Process of (3aR,4S,6R,6aS)-6-(N,N-dibenzylamino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol
There total 1 articles about (3aR,4S,6R,6aS)-6-(N,N-dibenzylamino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzyl bromide; (3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol;
With
potassium carbonate;
In
ethanol; water;
at 60 - 65 ℃;
for 3h;
With
ammonia;
In
ethanol; water;
for 0.25h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium t-butanolate / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / -10 - 5 °C
2.1: diisobutylaluminium hydride / toluene / 2.5 h / -25 - -20 °C
2.2: 0.25 h
3.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 10 h / 20 - 25 °C / 2327.23 Torr / Autoclave; Inert atmosphere
With
hydrogen; diisobutylaluminium hydride; sodium t-butanolate;
20% palladium hydroxide-activated charcoal;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium t-butanolate / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / -10 - 5 °C
2.1: diisobutylaluminium hydride / toluene / 2.5 h / -25 - -20 °C
2.2: 0.25 h
3.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 10 h / 20 - 25 °C / 2327.23 Torr / Autoclave; Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 - 25 °C
5.1: sodium hydrogencarbonate; sodium dithionite / water; acetone / 2 h / 20 - 25 °C
6.1: sodium azide; acetic acid / toluene; water / 1 h / 5 - 10 °C
7.1: iodine / acetone / 2 h / 25 - 60 °C
8.1: potassium carbonate / acetone / 20 h / 55 - 60 °C
9.1: hydrogenchloride; water / methanol / 5 h / 20 - 25 °C
9.2: 25 - 30 °C / pH 10
10.1: formic acid / palladium 10% on activated carbon / 50 °C
With
hydrogenchloride; formic acid; sodium azide; sodium dithionite; water; hydrogen; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium t-butanolate;
palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; toluene;
