Technology Process of Acetic acid 4a-benzyl-8-cyano-3,4,4a,5,6,7-hexahydro-naphthalen-2-yl ester
There total 7 articles about Acetic acid 4a-benzyl-8-cyano-3,4,4a,5,6,7-hexahydro-naphthalen-2-yl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 49 percent / potassium hydroxide / diethyl ether; ethanol / 4 h / 0 °C
2: p-toluenesulfonic acid / 3 h / 0 °C
3: 34 percent / 1.) phosphorous oxychloride, 2.) sodium acetate / 1.) methylene chloride, R.T. 4 h, 2.) 30 min.
4: 76 percent / hydroxylamine hydrochloride / methanol; pyridine / 0.5 h / Ambient temperature
5: 85 percent / trichloroacetonitrile / 0.5 h / Ambient temperature
6: 1.) conc. hydrochloric acid, 2.) triethylamine / 1.) THF, 1 h, 2.) benzene, 28 h
With
hydrogenchloride; potassium hydroxide; hydroxylamine hydrochloride; sodium acetate; toluene-4-sulfonic acid; triethylamine; trichloroacetonitrile; trichlorophosphate;
In
pyridine; methanol; diethyl ether; ethanol;
DOI:10.1139/v82-151
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 55 percent / 1.) dioxane, reflux 16 h, 2.) dioxane, water, reflux, 2.5 h
2: 49 percent / potassium hydroxide / diethyl ether; ethanol / 4 h / 0 °C
3: p-toluenesulfonic acid / 3 h / 0 °C
4: 34 percent / 1.) phosphorous oxychloride, 2.) sodium acetate / 1.) methylene chloride, R.T. 4 h, 2.) 30 min.
5: 76 percent / hydroxylamine hydrochloride / methanol; pyridine / 0.5 h / Ambient temperature
6: 85 percent / trichloroacetonitrile / 0.5 h / Ambient temperature
7: 1.) conc. hydrochloric acid, 2.) triethylamine / 1.) THF, 1 h, 2.) benzene, 28 h
With
hydrogenchloride; potassium hydroxide; hydroxylamine hydrochloride; sodium acetate; toluene-4-sulfonic acid; triethylamine; trichloroacetonitrile; trichlorophosphate;
In
pyridine; methanol; diethyl ether; ethanol;
DOI:10.1139/v82-151
- Guidance literature:
-
Multi-step reaction with 5 steps
1: p-toluenesulfonic acid / 3 h / 0 °C
2: 34 percent / 1.) phosphorous oxychloride, 2.) sodium acetate / 1.) methylene chloride, R.T. 4 h, 2.) 30 min.
3: 76 percent / hydroxylamine hydrochloride / methanol; pyridine / 0.5 h / Ambient temperature
4: 85 percent / trichloroacetonitrile / 0.5 h / Ambient temperature
5: 1.) conc. hydrochloric acid, 2.) triethylamine / 1.) THF, 1 h, 2.) benzene, 28 h
With
hydrogenchloride; hydroxylamine hydrochloride; sodium acetate; toluene-4-sulfonic acid; triethylamine; trichloroacetonitrile; trichlorophosphate;
In
pyridine; methanol;
DOI:10.1139/v82-151
