Technology Process of benzyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
There total 8 articles about benzyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate;
In
toluene;
at 100 ℃;
for 18h;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium hydroxide / ethylene glycol / 48 h / 150 °C
2: diphenylphosphoranyl azide; triethylamine / toluene / 4.75 h / 0 °C / Reflux
3: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 - 20 °C
4: acetic acid; sulfuric acid / 48 h / 20 °C
5: potassium hydroxide / water; ethylene glycol / 72 h / 150 °C
6: sodium hydroxide / tetrahydrofuran; water / 48 h / 0 °C
7: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 18 h / 100 °C / Sealed tube
With
tris-(dibenzylideneacetone)dipalladium(0); sulfuric acid; diphenylphosphoranyl azide; sodium hydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; triethylamine; potassium hydroxide; sodium hydroxide; sodium t-butanolate;
In
tetrahydrofuran; water; ethylene glycol; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 0 °C
1.2: 3 h / 20 °C
2.1: potassium hydroxide / ethylene glycol / 48 h / 150 °C
3.1: diphenylphosphoranyl azide; triethylamine / toluene / 4.75 h / 0 °C / Reflux
4.1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 - 20 °C
5.1: acetic acid; sulfuric acid / 48 h / 20 °C
6.1: potassium hydroxide / water; ethylene glycol / 72 h / 150 °C
7.1: sodium hydroxide / tetrahydrofuran; water / 48 h / 0 °C
8.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 18 h / 100 °C / Sealed tube
With
tris-(dibenzylideneacetone)dipalladium(0); sulfuric acid; diphenylphosphoranyl azide; sodium hydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; triethylamine; potassium hydroxide; sodium hydroxide; lithium hexamethyldisilazane; sodium t-butanolate;
In
tetrahydrofuran; water; ethylene glycol; toluene; mineral oil;
