benzyl 5-bromo-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:benzyl 5-bromo-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1430115-67-5
Molecular Formula:C₁₉H₂₀BrNO₂
Molecular Weight:374.277
Hs Code.:
Mol file:1430115-67-5.mol

Synonyms:benzyl 5-bromo-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of benzyl 5-bromo-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property:

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Technology Process of benzyl 5-bromo-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 7 articles about benzyl 5-bromo-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.8%

: 1430115-60-8
5-bromo-3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline

: 501-53-1,94274-21-2
benzyl chloroformate

: 1430115-67-5
benzyl 5-bromo-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 48h;

Reference yield:

: 1401437-29-3
1-bromo-2-(2-isocyanato-2-methylpropyl)benzene

: 1430115-67-5
benzyl 5-bromo-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 - 20 °C

2: acetic acid; sulfuric acid / 48 h / 20 °C

3: potassium hydroxide / water; ethylene glycol / 72 h / 150 °C

4: sodium hydroxide / tetrahydrofuran; water / 48 h / 0 °C

With sulfuric acid; sodium hydride; acetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; water; ethylene glycol; mineral oil;

Reference yield:

: 1430115-62-0
methyl 1-(2-bromophenyl)-2-methylpropan-2-ylcarbamate

: 1430115-67-5
benzyl 5-bromo-3,3-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sulfuric acid / 48 h / 20 °C

2: potassium hydroxide / water; ethylene glycol / 72 h / 150 °C

3: sodium hydroxide / tetrahydrofuran; water / 48 h / 0 °C

With sulfuric acid; acetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; water; ethylene glycol;