6-chloro-2-ethyl-N-(4-(1-(4-fluorobenzoyl)piperidin-4-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:6-chloro-2-ethyl-N-(4-(1-(4-fluorobenzoyl)piperidin-4-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1403941-04-7
Molecular Formula:C₂₉H₂₈ClFN₄O₂
Molecular Weight:519.018
Hs Code.:

Synonyms:6-chloro-2-ethyl-N-(4-(1-(4-fluorobenzoyl)piperidin-4-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of 6-chloro-2-ethyl-N-(4-(1-(4-fluorobenzoyl)piperidin-4-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of 6-chloro-2-ethyl-N-(4-(1-(4-fluorobenzoyl)piperidin-4-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide

There total 6 articles about 6-chloro-2-ethyl-N-(4-(1-(4-fluorobenzoyl)piperidin-4-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₅ClN₄O*C₂HF₃O₂

: 403-43-0
4-fluorobenzoyl chloride

: 1403941-04-7
6-chloro-2-ethyl-N-(4-(1-(4-fluorobenzoyl)piperidin-4-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: C₂₂H₂₅ClN₄O*C₂HF₃O₂; 4-fluorobenzoyl chloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

With hydrogenchloride;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1403941-04-7
6-chloro-2-ethyl-N-(4-(1-(4-fluorobenzoyl)piperidin-4-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: hydrogen / methanol / 3 h / 20 °C / 2327.23 Torr

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 8 h / 20 °C

4: dichloromethane / 5 h / 20 °C

5: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1403941-04-7
6-chloro-2-ethyl-N-(4-(1-(4-fluorobenzoyl)piperidin-4-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: hydrogen / methanol / 3 h / 20 °C / 2327.23 Torr

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 8 h / 20 °C

4: dichloromethane / 5 h / 20 °C

5: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;