1-BOC-4-(4'-CYANOPHENYL)PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-(4'-CYANOPHENYL)PIPERIDINE
• CAS No.: 162997-33-3
• Molecular Formula: C17H22N2O2
• Molecular Weight: 286.374
• Hs Code.: 2933399090
• Mol file: 162997-33-3.mol

Synonyms:1-BOC-4-(4-CYANOPHENYL)PIPERIDINE;tert-Butyl 4-(4-cyanocyclohexyl)piperidine-1-carboxylate

Chemical Property of 1-BOC-4-(4'-CYANOPHENYL)PIPERIDINE

Chemical Property:

• PSA: 53.33000
• LogP: 3.61068

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(4-cyanophenyl)-piperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-(4'-CYANOPHENYL)PIPERIDINE

There total 16 articles about 1-BOC-4-(4'-CYANOPHENYL)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-iodobenzonitrile (3058-39-7) + 1-(1-(tert-butoxycarbonyl)piperidin-4-yl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate → tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate (162997-33-3)

Guidance literature:

With manganese; (1,2-dimethoxyethane)dichloronickel(II); In N,N-dimethyl acetamide; chemoselective reaction;

DOI:10.1039/c9sc00783k

Reference yield: 84.0%

4-bromobenzenecarbonitrile (623-00-7) + 1-(1-(tert-butoxycarbonyl)piperidin-4-yl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate → tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate (162997-33-3)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 4,4'-di-tert-butyl-2,2'-bipyridine nickel(II) bromide; In N,N-dimethyl acetamide; at 20 ℃; for 24h; Irradiation; Inert atmosphere;

DOI:10.1039/d1sc00943e

Reference yield: 83.0%

4-fluorobenzonitrile (1194-02-1,143234-87-1) + tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate (375853-82-0,286961-14-6) → tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate (162997-33-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Inert atmosphere;

upstream raw materials:

1,4-bromoiodobenzene

N-benzyl-1-oxo-N-(penta-3,4-dien-1-yl)indane-2-carboxamide

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 4-(4-bromophenyl)-4-hydroxypiperidine-1-carboxylate

Downstream raw materials:

4-(1-(5-formyl-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile

4-(1-(2,4-dimethyl-5-(6-(pyrrolidin-1-yl)-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl)piperidin-4-yl)benzonitrile

4-(1-(3-formyl-4-methylbenzoyl)piperidin-4-yl)benzonitrile

5-(4-(4-cyanophenyl)piperidine-1-carbonyl)-2-methylbenzoic acid

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