N-(4-{[{[4-(1,1-dimethylethyl)phenyl]methyl}(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide

Base Information

• Chemical Name: N-(4-{[{[4-(1,1-dimethylethyl)phenyl]methyl}(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide
• CAS No.: 1508310-37-9
• Molecular Formula: C₃₁H₄₀N₂O₃S
• Molecular Weight: 520.736

Synonyms:N-(4-{[{[4-(1,1-dimethylethyl)phenyl]methyl}(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide

Chemical Property of N-(4-{[{[4-(1,1-dimethylethyl)phenyl]methyl}(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide

Chemical Property:

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Technology Process of N-(4-{[{[4-(1,1-dimethylethyl)phenyl]methyl}(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide

There total 6 articles about N-(4-{[{[4-(1,1-dimethylethyl)phenyl]methyl}(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.5%

4-tert-Butylbenzaldehyde (939-97-9) + 2-[4-(ethylsulfonyl)phenyl]-N-{4-[(propylamino)methyl]phenyl}acetamide (1508310-56-2) → N-(4-{[{[4-(1,1-dimethylethyl)phenyl]methyl}(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide (1508310-37-9)

Guidance literature:

4-tert-Butylbenzaldehyde; 2-[4-(ethylsulfonyl)phenyl]-N-{4-[(propylamino)methyl]phenyl}acetamide; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1021/ml4003875

Reference yield:

C20H24N2O3S → N-(4-{[{[4-(1,1-dimethylethyl)phenyl]methyl}(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide (1508310-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / Inert atmosphere

2.1: tetrahydrofuran / 1 h / 20 °C

2.2: 18 h / 20 °C

With sodium tetrahydroborate; In tetrahydrofuran; methanol;

DOI:10.1021/ml4003875

Reference yield:

2-[4-(ethylsulfonyl)phenyl]-N-(4-formylphenyl)acetamide (1508310-55-1) → N-(4-{[{[4-(1,1-dimethylethyl)phenyl]methyl}(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide (1508310-37-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium sulfate / dichloromethane / 72 h / 20 °C

2.1: sodium tetrahydroborate / methanol / Inert atmosphere

3.1: tetrahydrofuran / 1 h / 20 °C

3.2: 18 h / 20 °C

With sodium tetrahydroborate; sodium sulfate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/ml4003875

upstream raw materials:

4-nitrobenzaldehdye

2-(4-nitrophenyl)-1,3-dioxolane

4-(1,3-dioxolan-2-yl)aniline

2-[4-(ethylsulfonyl)phenyl]-N-(4-formylphenyl)acetamide

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