3-Bromo-1-fluoronaphthalene

Base Information

• Chemical Name: 3-Bromo-1-fluoronaphthalene
• CAS No.: 13772-59-3
• Molecular Formula: C10H6BrF
• Molecular Weight: 225.06
• Hs Code.: 2903999090
• Mol file: 13772-59-3.mol

Synonyms:1-Naphtylmethyl bromide

Chemical Property of 3-Bromo-1-fluoronaphthalene

Chemical Property:

• Appearance/Colour: white solid powder
• Vapor Pressure: 0.00584mmHg at 25°C
• Refractive Index: 1.638
• Boiling Point: 282.104 °C at 760 mmHg
• Flash Point: 128.005 °C
• PSA: 0.00000
• Density: 1.564 g/cm³
• LogP: 3.74140
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-1-fluoronaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-1-fluoronaphthalene

There total 6 articles about 3-Bromo-1-fluoronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-bromo-1-fluoronaphthalene (317-79-3) → 3-bromo-1-fluoronaphthalene (13772-59-3)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -75 ℃; for 6h;

DOI:10.1002/ejoc.200500514

Reference yield:

4-Fluoro-1-aminonaphthalene (438-32-4) → 3-bromo-1-fluoronaphthalene (13772-59-3)

Guidance literature:

Multistep reaction; (i) HBr, EtOH, (ii) NaNO₃, H₂SO₄, (iii) Cu₂O;

DOI:10.1021/ja00978a038

Reference yield:

1-fluoro-4-nitronaphthalene (341-92-4) → 3-bromo-1-fluoronaphthalene (13772-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd-C / ethanol

2: (i) HBr, EtOH, (ii) NaNO₃, H₂SO₄, (iii) Cu₂O

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/ja00978a038

upstream raw materials:

3-bromonaphthalen-1-amine

4-Fluoro-1-aminonaphthalene

2-bromo-1-fluoronaphthalene

1-Fluoronaphthalene

Downstream raw materials:

3-bromo-1-fluoro-2-iodonaphthalene

(1-fluoronaphth-3-yl)diphenylphosphane oxide

1,1'-difluoro-3,3'-bis(diphenylphosphoryl)-2,2'-binaphthyl

(4-fluoronaphthalen-1-yl)boronic acid