1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine

Base Information

Chemical Name:1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine
CAS No.:1000305-04-3
Molecular Formula:C₁₅H₂₀BrN
Molecular Weight:294.235
Hs Code.:

Synonyms:1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine

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Chemical Property of 1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine

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Technology Process of 1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine

There total 10 articles about 1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1366440-28-9
C₁₅H₁₈BrNO

: 1000305-04-3
1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine

Guidance literature:: C₁₅H₁₈BrNO; With borane-THF; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; at 65 ℃; Inert atmosphere;

With sodium hydroxide; In water; at 20 ℃; pH=10;

Reference yield:

: 1000305-05-4
(1S,2S)-2-(4-bromophenyl)cyclopropanecarbaldehyde

: (S)-(+)-2-Methylpyrrolidine (-)-hydrogen tartrate adduct

: 1000305-04-3
1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine

Guidance literature:: (1S,2S)-2-(4-bromophenyl)cyclopropanecarbaldehyde; (S)-(+)-2-Methylpyrrolidine (-)-hydrogen tartrate adduct; With sodium cyanoborohydride; In ethanol; at 20 ℃; for 2h;

With sodium hydroxide; In ethanol; water; pH=10 - 12; Product distribution / selectivity;

Reference yield:

: 77255-26-6,2137065-16-6
trans-2-(4-bromophenyl)cyclopropanecarboxylic acid

: 1000305-04-3
1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C

1.2: 15 - 20 °C

2.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere

2.2: 65 °C / Inert atmosphere

2.3: 20 °C / pH 10

With borane-THF; 1,1'-carbonyldiimidazole; In tetrahydrofuran;