4-{2-[(2S)-2-methyl-pyrrolidin-1-ylmethyl]-(1S,2S)-cyclopropyl}-phenylamine

Base Information

Chemical Name:4-{2-[(2S)-2-methyl-pyrrolidin-1-ylmethyl]-(1S,2S)-cyclopropyl}-phenylamine
CAS No.:1000305-12-3
Molecular Formula:C₁₅H₂₂N₂
Molecular Weight:230.353
Hs Code.:

Synonyms:4-{2-[(2S)-2-methyl-pyrrolidin-1-ylmethyl]-(1S,2S)-cyclopropyl}-phenylamine

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Chemical Property of 4-{2-[(2S)-2-methyl-pyrrolidin-1-ylmethyl]-(1S,2S)-cyclopropyl}-phenylamine

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Technology Process of 4-{2-[(2S)-2-methyl-pyrrolidin-1-ylmethyl]-(1S,2S)-cyclopropyl}-phenylamine

There total 1 articles about 4-{2-[(2S)-2-methyl-pyrrolidin-1-ylmethyl]-(1S,2S)-cyclopropyl}-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000305-04-3
1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine

: 1000305-12-3
4-{2-[(2S)-2-methyl-pyrrolidin-1-ylmethyl]-(1S,2S)-cyclopropyl}-phenylamine

Guidance literature:: With lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In hexane; toluene; at 160 ℃; for 0.666667h; Product distribution / selectivity; microwave irradiation;

Reference yield:

: 1000305-12-3
4-{2-[(2S)-2-methyl-pyrrolidin-1-ylmethyl]-(1S,2S)-cyclopropyl}-phenylamine

: 78-84-2
isobutyraldehyde

: 1000304-77-7
N-isobutyl-N-[4-((1S,2S)-2-{[(2S)-2-methylpyrrolidin-1-yl]methyl}cyclopropyl)phenyl]amine

Guidance literature:: With borane pyridine; In ethanol; at 20 ℃; for 16h;

Reference yield:

: 243977-22-2
5-(trifluoromethyl)thieno[3,2-b]pyridine-6-carboxylic acid

: 1000305-12-3
4-{2-[(2S)-2-methyl-pyrrolidin-1-ylmethyl]-(1S,2S)-cyclopropyl}-phenylamine

: N-[4-((1S,2S)-2-{[(2S)-2-methylpyrrolidin-1-yl]methyl}cyclopropyl)phenyl]-5-(trifluoromethyl)thieno[3,2-b]pyridine-6-carboxamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 16h;